Monday 2 October 2017, 1.00PM
Speaker(s): Natalia A Riobo-Del Galdo, University of Leeds
The morphogen Sonic Hedgehog (Shh) has been proposed as a therapeutic agent for ischemic cardiac injuries due to its proangiogenic properties. Binding of Shh to its receptor Patched1 derepresses the 7-transmembrane protein Smoothened (Smo), leading to slow induction of Gli-dependent transcription and to rapid non-canonical signalling by stimulation of heterotrimeric G inhibitory proteins (Gi). Since Gi has a central function in the regulation of cardiac physiology, we hypothesized that non-canonical Hedgehog (Hh) signalling would alter the electrophysiological properties of the heart. Our findings suggest that Smo/Gi non-canonical signalling mediates potassium ionic channel remodelling in cardiomyocytes and sensitizes the heart to the development of ventricular arrhythmias, discouraging its use as a cardioprotective agent.
More information on Natalia's work can be found here.
The host for this seminar is William J. Brackenbury.