Mechanisms that regulate adipocyte progenitor maintenance and differentiation in the skin

Monday 25 September 2017, 1.00PM

Speaker: Dr Guillermo Rivera-Gonzalez, Yale University

I got my Bachelor’s degree at the Mexican National Autonomous University in Mexico in 2006. After finishing my Master’s studies in 2008 I started my PhD studies in Professor Norman Maitland's laboratory at the University of York where I worked on the study of prostate-specific gene expression and gene therapy for prostate cancer. In 2012, I started a postdoctoral position in the laboratory of Dr. Valerie Horsley at Yale University where I currently investigate the biology of adipocyte precursors and adipocyte stem cells in the skin. Adipose tissue in the skin contributes to wound healing, hair growth, the response to bacterial infection and the onset of fibrosis. Therefore, understanding how adipose tissue is maintained is a priority in the design of new therapies that aim to improve skin’s health. My main finding during my postdoc has been the identification of PDGFA as a key factor in the maintenance of skin adipocyte stem cells. During my talk I will show data that suggests that PDGFA activates the PI3K/AKT signaling cascade, leading to the proliferation and maintenance of adipocyte stem cells in the skin. I will also show data suggesting that PI3K/AKT signaling is be involved in adipocyte stem cell differentiation and I am currently working on understanding the complex molecular mechanisms that regulate the commitment of adipocyte precursors into mature adipocytes. Together, my research aims to understand how adipose tissue is generated and maintained in the skin, which will lead to the development of therapies and treatments that can be used to improve skin health.

The host for this seminar is Professor Norman J Maitland. 

Location: K018