Posted on 6 December 2016
The team found that the final stages of the production of artemisinin, a substance used in anti-malarial drugs and naturally harvested from the plant, Artemisia annua, is a spontaneous process and does not involve the actions of proteins to trigger a chemical reaction.
This spontaneous process means that a very particular chemical environment must be created in order to produce and store often toxic chemicals in the plant.
The findings, published in the journal, Proceedings of the National Academy of Sciences (PNAS), suggest that companies could potentially utilise this 'chemical factory' system within the plant itself for use in the production of a whole host of chemical-based products, such as anti-bacterial gels, fragrances, natural sweeteners, and compounds to aid food crop production.
Professor Ian Graham from the Centre for Novel Agricultural Products (CNAP), who led the research, explains: "Plants make lots of high value compounds but often in very small amounts. To produce these compounds on a commercial scale industrial biotechnologists aim to transfer the whole production process from plants to yeast cells which can then be grown at scale in large fermenters. Many of the valuable plant compounds, however, can be toxic to yeast cells. Our new findings, suggests that we may have a solution to this problem."
The study shows that the 'chemical factory', called glandular trichomes, not only produces complex chemicals, but can store them without being toxic to the plant. The team also found that the pathway that produces artemisinin can be diverted to make entirely new products. The researchers argue that using the plant itself as the 'factory' can work in creating products on a commercial scale.
Dr Tomasz Czechowski, co-author of the research paper at the University of York, said: "We have shown that Artemisia annua not only produces the most effective medicine to cure people suffering form malaria but it can also be altered to produce other complex molecules, which is an exciting discovery. We now know that it employs a very sophisticated system that stores complex chemicals that could be used in many other products. This could pave the way for other plant-based products being made naturally within the plant itself."
The paper can be found here: Czechowski PNAS paper 2016 (PDF , 1,132kb)