JBU Self-funded PhD Studentships

(example below)

Project Title

Homeostatic mechanisms in human urothelium: balancing of tissue regeneration and differentiation with implications for regenerative medicine and cancer

The urothelium is the self-regenerating epithelium that lines the bladder, where it is highly specialised to function as a urinary barrier.  Although normally a mitotically-quiescent tissue, urothelium shows a rapid and highly regenerative response to damage.  Whether there is a specific progenitor or stem cell population remains controversial, as no such cell has been unequivocally identified. An alternative hypothesis is that all cells remain capable of switching into a regenerative phenotype, irrespective of differentiation state.  The project will examine this hypothesis in a well-established cell culture system, using a combination of cell and molecular biology approaches to examine the role of cell:cell interactions, downstream signal transduction and epigenetic regulation.  

Supervisor: Professor Jennifer Southgate (Biology JBU)

Please contact Professor Jennifer Southgate:  J.southgate@york.ac.uk  if you would like to discuss this or other self-funded projects that may be available.