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The Clarke Group

 

 

Chemistry   

 

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The Clarke Group

Welcome

Research Interests

Research Papers

Research Lectures

Meet the Group

Vacancies

Information

Group Resources

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Group information and news.

 

The Daily Mail Newspaper ran a story on some of the group’s research on the prebiotic genesis of carbohydrates. Congratulations to Laurence who is the only group member to have been cited by a national newspaper! The Daily Mail article can be found here: http://tinyurl.com/83pkuhd and the original paper here: http://pubs.rsc.org/en/content/articlelanding/2011/ob/c1ob06798b

 

Congratulations Laurence and Joby who passed their PhD vivas in Nov 2011.

 

Well done Nimesh who was appointed as an organic chemistry teaching fellow at the University of York in Oct 2011. Is Nimesh a poacher turned gamekeeper?

 

Congratulations Mudassar, Andrew and Nimesh who all passed their PhD vivas in Dec 2010. Mudassar is taking up an academic position in Pakistan, Andrew is considering the opportunities a PhD gives him and Nimesh is rejoining the group in Jan 2011 as a Wellcome VIP Fellow.

 

The Group Welcomes Kristaps Ermanis and Bun Yeung who joined the group in Oct 2010 to conduct postgraduate research.

 

The Group’s Paper on the Prebiotic Synthesis of (D)-Threose and (D)-Erythrose has been highlighted as a HOT ARTICLE on the Chem. Comm. website on 17th June 2010.

 

Well done Joby on winning first prize in the RSC organic division’s regional meeting poster competition which was held in Durham on 15th April 2010.

 

Welcome to Nadia and Myriam who both joined the group as ERASMUS students in April.

 

Good Luck to Joby, who has been selected to give a lecture at the SCI postgraduate symposium in Manchester on 31st March 2010.

 

Good Luck for the Future Elin. Elin left the group at the end of 2009. She has now moved to Germany to continue her career.

 

Congratulations Jason! Jason Hargreaves has been awarded a PhD in Nov 2009 for his work on the total synthesis of phorboxazole B. Jason is off to a postdoctoral research position in Paris, France, in Feb 2010.

 

The Group Welcomes Zhuo Ma, who has joined the group in Oct 2009, from China to study for a PhD.

 

Dr. Paul Clarke has been made a Fellow of the Royal Society of Chemistry.

 

Welcome to Dominik Bucher who joined the group as a visiting student from Munich in Sept 2009 for 8 weeks.

 

The Group’s method for the PASE synthesis of piperidines detailed in Tetrahedron Lett. 2007, 48, 5209 has been used by Central Drug Research Institute, Lucknow, India to synthesise compounds with sub-micromolar anti-malarial activity. See Bioorg. Med. Chem. 2009, 17, 625.

 

Congratulations to Soraia and Gabriele who were both awarded their PhDs in November 2008. Soraia is continuing to work at Peakdale, while Gabriele has moved back to Italy to take up a postdoctoral research position.

 

Group’s Paper on the Four-Component Piperidine Synthesis has been highlighted in Synfacts 2008, 11, 1026.

 

Welcome to Philip Sellars who joined the group as a PhD student in Oct 2008.

 

Dr. Paul Clarke is on a lecture tour of Australia in August 2008, and will be presenting a lecture at the Heron Island conference on Radical Chemistry.

 

Welcome to Dr. Elin Abraham who joined the group in May 2008. Elin is working on the total synthesis of phorboxazole B.

 

Good Luck and Best Wishes to Soraia, Gabriele and Maggie who left the group at the end of 2007. Soraia and Gabriele have secured jobs at Peakdale and Maggie is starting a PhD at Cambridge in the New Year.

 

Welcome to Dr. Dan Woollaston who joined the group in Jan 2008.

 

Group’s Paper on the Pot, Atom and Step Ecomonic (PASE) synthesis of highly substituted piperidines has been highlighted in Synfacts 2007, 10, 1031.

 

Welcome to Joby Winn and Laurence Burroughs  who joined the group in Oct 2007 as PhD students.

 

EPSRC funds a research grant for a postdoc and student to conduct the total synthesis of the pinguisane-type sesquiterpenoid natural products. The grant starts Oct 1st 2007.

 

Dr. Paul Clarke will be giving his Roche Lecture at the Roche site in Basel, Switzerland on 24th Sept. The lecture is entitled “Novel Annelation and Transannelation Strategies for the Synthesis of Natural Products”.

 

Congratulations Andrew! Andrew Cridland was awarded a PhD on 24th July 2007, for his work on the synthesis of the ABC-rings of hexacyclinic acid. Andy is now working at the GSK site in Harlow, UK.

 

Dr. Paul Clarke is giving an invited lecture at the US-UK Synthesis workshop in San Francisco in July/August 2007.

 

Dr. Paul Clarke is on a lecture tour of Australia in June and July 2007, and will be presenting a lecture at the Heron-4 conference on “Synthesis and Mechanism: Reactive Intermediates and Unusual Molecules”

 

Florie Lavigne joined the group in April 2007 as an Erasmus exchange student.

 

Good luck Wencke. Wencke left the group at the end of April 2007 after working in the group for two years. We wish Wencke all the best for the future.

 

Gabriele Rolla and Soraia Santos presented posters at the ACS meeting in Chicago in March 2007.

 

Mudassar Iqbal joined the group in Jan 2007 as a Higher Education Commission of Pakistan 10% Overseas Scholar, studying towards a PhD.

 

Dr. Paul Clarke awarded a Pfizer bursary for the 2007 RSC Cambridge Synthesis Meeting.

 

Congratulations! Richard Black awarded a PhD on 13th November 2006, for his work on the transannulation reactions of nine membered rings and their application to natural product synthesis. Richard is moving to Australia in 2007 to conduct postdoctoral research.

 

We are please to welcome Andrew Reeder, Nimesh Mistry, Dr. Andrey Zaytzev and Mei-Hsuan Tsai who joined the group on 2nd Oct 2006.

 

Good luck Mat. Mat Vale left the group at the end of July 2006 to embark upon a postgraduate medical degree at Newcastle. We wish Mat all the best for the future and his new career.

 

Goodbye Nigel. Nigel Bainbridge left the group at the end of June 2006 to take up a position as a research chemist at Evotec. We wish Nigel all the best in his new job.

 

Congratulations Andrew! Andrew Cridland has secured a job as a medicinal chemist at GSK, Harlow. Andy will start work at GSK after he has finished his PhD studies in January 2007.

 

Dr. Paul Clarke awarded an AstraZeneca collaborative research award starting Oct 2006.

 

Andrew Cridland gave a lecture on his research at the SCI (North) postgraduate meeting in York on 19th April 2006.

 

Alastair Wilcox will join the group in Jan 2006.

 

The Clarke Group is moving to the University of York. From Jan 2006, the group will be based in the Department of Chemistry at the University of York. Applications for postdoctoral and Ph.D. positions in the group at York are welcome. Please contact us if you would like more information.

 

Jason Hargreaves joined the group in October 2005.

 

EPSRC Grant awarded to fund postdoctoral research into Pot, Atom and Step Economic (PASE) synthesis of highly functionalised heterocyclic molecules.

 

Martin Smith awarded a PhD on 26th Sept 2005, for his work on the lanthanide (III) salt catalysed desymmetrisation of 1, 2-diols. Congratulations Martin.

 

Andrew Cridland wins the Leslie Crombie Prize for best poster at the School of Chemistry’s annual postgraduate symposium on 16-17th June 2005.

 

Dr. Paul Clarke awarded the Roche, Basel Collaborative Research Award 2005, and the Roche, Basel Lectureship for 2007.

 

Dr. Wencke Steinle joins the group in May 2005, to work on the total synthesis of the marine natural product phorboxazole A.

 

Congratulations! Will Martin awarded a PhD on 9th March 2005, for his work on the revisited Maitland-Japp reaction, which constructs highly substituted tetrahydropyrans rings in a single pot. Will has now joined the group of Prof. Blechert in Berlin.

 

EPSRC Postdoc and Studentship Grant awarded to fund research into the total synthesis of the potent anti-cancer natural product phorboxazole A.

 

Dr. Nigel Bainbridge  will join the group in January 2005, to work on the total synthesis of Hexacyclinic acid and FR182877.

 

Gabriele Rolla and Soraia Santos  joined the group in October 2004.

 

EPSRC Postdoc and Studentship Grant awarded for studies on the total synthesis of FR182877 and hexacyclinic acid.

 

Becky Davie awarded a PhD on 16th July 2004, for her work on the Diels-Alder and rearrangement reactions of 6-fumaryl 1,3,8-nonatrienes, as an approach to the B-ring of FR182877. Congratulations Becky!

 

Will Martin wins First Prize for an oral presentation on his Ph.D. research at the School of Chemistry’s annual postgraduate symposium on 17-18th June 2004.

 

Matthew Grist awarded a PhD for his work on a novel transannular iodocyclisation approach to the DEF-ring cores of the natural products hexacyclinic acid and FR182877 on Wednesday 21st April 2004. Congratulations Matt!

 

Will Martin wins First Prize for an oral presentation on his Ph.D. research at the SCI postgraduate meeting (North) at the University of York on Monday 29th March 2004.

 

Dr. Paul Clarke awarded the AstraZeneca Young Investigator Unrestricted Research Award 2003-2005.

 

 

For more information on the group please use the links on this web page or contact us at the address below.

 

 

Contact Details

Dr. Paul A. Clarke,
Department of Chemistry,
University of York
Heslington,
York, YO10 5DD, UK.

Phone: +44 1904 432614
E-mail: pac507@york.ac.uk

 

 

 

 

 

 

 

 

 

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