Welcome to the Gideon Davies group website
The Davies group probes the biological chemistry of carbohydrates: from enzymes and their chemistries through to in vivo applications of chemistry. We use protein crystallography, enzyme kinetics, calorimetry, enzyme inhibition and imaging to study the structural enzymology of proteins involved in the synthesis, modification and degradation of diverse glycoconjugates, oligo- and polysaccharides.
We have active projects involved in processes as diverse as the O-GlcNAc modification of higher eukaryotes, Cu-catalysed deconstructon of plant cell walls, the impact of diet on the intestinal microbiota, diverse glycosidases and glycoside hydrolases and the synthesis of bioactive opiates.
One of the groups's major areas of research is the fundamental study of enzyme reaction coordinates - the conformational analysis of enzymes - in order to unveil the secrets of catalysis and inform strategies for therapeutic intervention.
Some recent publications
Larsbrink et al. 2014. A discrete genetic locus confers select Bacteroidetes with a niche capacity for xyloglucan metabolism in the human gut. Nature Online http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12907.html
Hemsworth et al., 2014. Discovery of a new family of lytic polysaccharide mono-oxygenases. Nature Chemical Biology 10, 122-126.
William et al., 2014. Combined inhibitor free energy landscape and structural analysis reports on the mannosidase conformational coordinate. Angew Chemie Int Ed 53, 1087-1091
Hemsworth et al., 2013. The copper active site of CBM33 polysaccharide oxygenases. J Am Chem Soc 135, 6069-6077.
Thompson et al., 2012. Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase. Proc Natl Acad Sci (USA) 109, 781-786.
He et al 2010. Visualizing the reaction coordinate of an O-GlcNAc hydrolase. J Am Chem Soc 132 , 1807-1809.
Hemsworth et al 2013. Recent insights into copper-containing lytic polysaccharide mono-oxygenases.Curr Opin Struct Biol 23, 660–668
Hurtado-Guerrero and Davies. 2012. Recent structural and mechanistic insights into post-translational enzymatic glycosylation. Curr Opin Chem Biol 16, 479-487.
Davies et al., 2012. Conformational analyses of the reaction coordinate of glycosidases. Accounts Chem Res 45, 227-234.
Check out the "News" section for more details.
PhD positions for Oct 2014
2-3 Ph.D positions are potentially available. Contact me directly.