Welcome to the Gideon Davies group website
The Davies group probes the biological chemistry of carbohydrates: from enzymes and their chemistries through to in vivo applications of chemistry. We use protein crystallography, enzyme kinetics, calorimetry, enzyme inhibition and imaging to study the structural enzymology of proteins involved in the synthesis, modification and degradation of diverse glycoconjugates, oligo- and polysaccharides.
We have active projects involved in processes as diverse as the O-GlcNAc modification of higher eukaryotes, Cu-catalysed deconstructon of plant cell walls, the impact of diet on the intestinal microbiota, diverse glycosidases and glycoside hydrolases and the synthesis of bioactive opiates.
One of the groups's major areas of research is the fundamental study of enzyme reaction coordinates - the conformational analysis of enzymes - in order to unveil the secrets of catalysis and inform strategies for therapeutic intervention.
Some recent publications
Hemsworth et al., 2013. The copper active site of CBM33 polysaccharide oxygenases. J Am Chem Soc 135, 6069-6077.
Thompson et al., 2012. Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase. Proc Natl Acad Sci (USA) 109, 781-786.
Thompson et al., 2012. The reaction coordinate of a bacterial GH47 α-mannosidase: a combined quantum mechanical and structural approach. Angew Chemie Int Ed 51, 10997-11001 (selected as VIP paper).
Lee et al 2011. Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase. Nature Chem Biol 7, 631–638.
Quinlan et al., 2011 Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components Proc Natl Acad Sci (USA) 108, 15079-15084.
He et al 2010. Visualizing the reaction coordinate of an O-GlcNAc hydrolase. J Am Chem Soc 132 , 1807-1809.
Hemsworth et al., 2013. Recent insights into copper-containing lytic polysaccharide mono-oxygenases. Curr Opin Struct Biol in press http://dx.doi.org/10.1016/j.sbi.2013.05.006.
Hurtado-Guerrero and Davies. 2012. Recent structural and mechanistic insights into post-translational enzymatic glycosylation. Curr Opin Chem Biol 16, 479-487.
Davies et al., 2012. Conformational analyses of the reaction coordinate of glycosidases. Accounts Chem Res 45, 227-234.
Check out the "News" section for more details.
PhD positions for Oct 2014
2-3 Ph.D positions are potentially available. Contact me directly.