{"text_format":"1","workbook":"xlsx","n_sheets":6,"sheets":["Introduction","Price inputs","Results","Calculations 1","Calculations 2","Calculations 3"],"not_rendered":{"charts":0,"images":0,"macros":1,"external_links":0,"defined_names":152,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Introduction","index":0,"n_rows":55,"n_cols":11,"rows_kept":55,"cut":false,"hidden":false,"merged":[[51,2,51,19],[30,3,30,19],[43,2,43,19],[34,2,34,19],[35,2,35,19],[36,3,36,19],[37,3,37,19],[38,3,38,19],[39,3,39,19],[40,3,40,19],[25,3,25,19],[29,3,29,19],[13,2,13,19],[14,3,14,19],[15,3,15,19],[16,3,16,19],[27,3,27,19],[24,3,24,20],[26,3,26,19],[28,3,28,19],[2,2,2,19],[8,2,8,19],[21,3,21,19],[22,3,22,19],[23,3,23,19]]}
[]
[]
[null,null,"Tool to calculate the cost-effective strategy for user-defined prices and cost-effectiveness thresholds"]
[]
[null,null,"For full report on model and analysis see Faria et al. 'Prevention of progression to cirrhosis in hepatitis C with fibrosis: effectiveness and cost-effectiveness of sequential therapy'. 2016"]
[]
[null,null,"Introduction"]
[]
[null,null,"This tool calculates the cost-effective sequence of treatment for patient groups with chronic hepatatis C infection using user-defined prices (or price discounts) and cost-effectiveness threshold. \nHealth benefits are expressed as quality-adjusted life years (QALYs) over the patients' lifetime. Costs are in UK pound sterling. Only costs falling on the NHS budget were included."]
[]
[null,null,"Patient populations"]
[]
[null,null,"The population is patients with chronic hepatitis C infection with advanced fibrosis but pre-cirrhotic (METAVIR F3). "]
[null,null,"The population is divided into 14 subgroups depending on viral genotype, exposure to prior treatment and eligibility to interferon-containing treatments:"]
[null,null,null,"By viral genotype: genotype 1, genotype 2, genotype 3 and genotype 4 virus."]
[null,null,null,"By exposure to prior treatment: treatment-naïve, treatment-experienced to interferon or treatment-experienced to protease inhibitors."]
[null,null,null,"Eligible or ineligible for interferon-containing regimens. treatment naive patients are assumed to include some patients who are eligible for interferon-containing regimens and some who are not. "]
[]
[null,null,"Treatments included"]
[]
[null,null,"The tool, and the cost-effectiveness analysis on which it is based on, compares treatment strategies with one, two or three lines of treatment. The treatments included are:"]
[null,null,null,"PR: Peginterferon alfa-2a with ribavirin for 24 weeks for treatment-naïve genotypes 2 and 3; 48 weeks for treatment-naïve genotypes 1 and 4 and all treatment-experienced patients."]
[null,null,null,"SMV+PR: Simeprevir with PR where SMV is given over 12 weeks and PR is given over 24 weeks for treatment-naïve and prior relapsers and 48 weeks for treatment-experienced (prior null or partial responders)."]
[null,null,null,"SOF+PR: Sofosbuvir with PR where SOF is given over 12 weeks for genotypes 1, 3 and 4."]
[null,null,null,"SOF+RBV: Sofosbuvir with ribavirin given over 12 weeks for genotype 2 and over 24 weeks for genotypes 1, 3 and 4."]
[null,null,null,"SOF+LED: Ledipasvir-sofosbuvir given over 8 weeks for genotype 1 treatment-naive, 12 weeks for genotype 4 treatment-naïve and genotypes 1 and 4 treatment-experienced."]
[null,null,null,"SOF+LED+RBV: given over 12 weeks for HCV genotype 3. "]
[null,null,null,"2D+RBV: Ombitasvir, paritaprevir and ritonavir with ribavirin given over 12 weeks for HCV genotype 4. "]
[null,null,null,"3D+/-RBV: Ombitasvir, paritaprevir, ritonavir and dasabuvir with or without ribavirin given over 12 weeks for genotype 1. "]
[null,null,null,"SOF+DCV: Daclatasvir with SOF given over 12 weeks for genotypes 1, 3 and 4."]
[null,null,null,"DCV+PR: Daclatasvir over 24 weeks with PR over 48 weeks for genotype 4 "]
[]
[null,null,"Interpretation of results"]
[]
[null,null,"The cost-effective sequence for each subgroup is that which achieves the greatest net health gains. The rationale is that costs can be expressed as health losses using the cost-effectiveness threshold. The cost-effectiveness threshold represents the marginal cost of producing one QALY in the current health care system. "]
[null,null,"For each subgroup, the cost-effectiveness results are presented at a per patient basis and include:"]
[null,null,null,"The treatments composing the cost-effective sequence and their position in the sequence (1st, 2nd or 3rd line). "]
[null,null,null,"The proportion of patients achieving sustained virologic response (SVR) at each treatment line. "]
[null,null,null,"The cost of each treatment line. "]
[null,null,null,"The lifetime costs of the treatment strategy, discounted at 3.5% per annum."]
[null,null,null,"The lifetime QALYs of the treatment strategy, discounted at 3.5% per annum."]
[null,null,null,"The incremental cost-effectiveness ratio (ICER). "]
[]
[null,null,"The results for the treatment-experienced subgroups reflect the full treatment pathway experienced by the patient, including their first line treatment (PR or protease inhibitor+PR)"]
[]
[null,null,"How to use the tool"]
[]
[null,null,"Click here to go to the inputs sheet where you can input your prices and cost-effectiveness threshold. "]
[]
[null,null,"Methods"]
[]
[null,null,"For more details on parameter inputs and structure of cost-effectiveness model see the Technical Appendix in the aformentioned paper."]
[]
[]
[null,null,"Click here to make calculation sheets visible: ",null,null,null,null,null,null,null,"Click here to make calculaton sheets invisible: "]

{"sheet":"Price inputs","index":1,"n_rows":24,"n_cols":11,"rows_kept":24,"cut":false,"hidden":false,"merged":[[20,4,20,8]]}
[]
[]
[]
[]
[]
[]
[null,null,"Price inputs"]
[]
[null,null,"Generic name","Brand name","Packet size","New price","OR","Discount",null,"UK list price"]
[null,null,"Sofosbuvir","Sovaldi",28,null,null,null,null,11660.98]
[null,null,"Simeprevir","Olysio",7,null,null,null,null,1866.5]
[null,null,"Pegylated interferon","Pegasys 180mcg",1,null,null,null,null,124]
[null,null,"Ribavirin","Copegus",168,null,null,null,null,321.38]
[null,null,"Ledipasvir-Sofosbuvir","Harvoni",28,null,null,null,null,12993.33]
[null,null,"Ombitasvir-paritaprevir-ritonavir","Viekirax",56,null,null,null,null,10733.33]
[null,null,"Dasabuvir","Exciera",56,null,null,null,null,933.33]
[null,null,"Daclatasvir","Daclinza",28,null,null,null,null,8172.61]
[null,null,null,null,null,null,null,null,null,"This is the price used as default"]
[null,null,null,null,null,"Insert EITHER the new price OR the % discount in the green box"]
[]
[null,null,"Cost-effectiveness threshold",20000,"Insert the relevant cost-effectiveness threshold; default is",null,null,null,null,20000,"per QALY gained"]
[]
[]
[null,null,null,null,"Press this button for the model to calculate the cost-effective strategies"]

{"sheet":"Results","index":2,"n_rows":30,"n_cols":15,"rows_kept":30,"cut":false,"hidden":false,"merged":[[6,3,6,5],[6,6,6,8],[6,9,6,11],[6,14,7,14],[22,14,23,14],[22,3,22,5],[22,6,22,8],[22,9,22,11],[17,2,17,14],[18,2,18,14]]}
[]
[]
[null,null,"Results: Cost-effective strategy for each subgroup"]
[]
[null,null,"Treatment-naïve patients"]
[]
[null,null,null,"Cost-effective strategies",null,null,"% Patients achieving SVR by line",null,null,"Treatment cost by line",null,null,"Total","Total","ICER"]
[null,null,"Subgroup","1st line","2nd line","3rd line","1st ","2nd ","3rd ","1st ","2nd ","3rd ","Costs ","QALYs "]
[null,null,"Genotype 1 interferon ineligible ",{"$f":"IF('Calculations 3'!V11=\"\",\"\",VLOOKUP('Calculations 3'!V11,F3_treat_duration,14,FALSE))","v":"SOF+LED 8w"},{"$f":"IF('Calculations 3'!W11=\"\",\"\",VLOOKUP('Calculations 3'!W11,F3_treat_duration,14,FALSE))","v":"3D+/-RBV 12w"},{"$f":"IF('Calculations 3'!X11=\"\",\"\",VLOOKUP('Calculations 3'!X11,F3_treat_duration,14,FALSE))","v":"SOF+DCV 12w"},{"$f":"'Calculations 3'!AA11","v":0.91891964127642312},{"$f":"'Calculations 3'!AB11","v":5.9627131966183099E-2},{"$f":"'Calculations 3'!AC11","v":2.3030878764844125E-3},{"$f":"'Calculations 3'!AD11","v":25917.98},{"$f":"'Calculations 3'!AE11","v":2229.91},{"$f":"'Calculations 3'!AF11","v":145.08000000000001},{"$f":"'Calculations 3'!AG11","v":29699.8},{"$f":"'Calculations 3'!AH11","v":12.05162912590459},{"$f":"'Calculations 3'!AI11","v":10867.285847714487}]
[null,null,"Genotype 1 interferon eligible",{"$f":"IF('Calculations 3'!V12=\"\",\"\",VLOOKUP('Calculations 3'!V12,F3_treat_duration,14,FALSE))","v":"SOF+LED 8w"},{"$f":"IF('Calculations 3'!W12=\"\",\"\",VLOOKUP('Calculations 3'!W12,F3_treat_duration,14,FALSE))","v":"3D+/-RBV 12w"},{"$f":"IF('Calculations 3'!X12=\"\",\"\",VLOOKUP('Calculations 3'!X12,F3_treat_duration,14,FALSE))","v":"SOF+PR 12w"},{"$f":"'Calculations 3'!AA12","v":0.91896831033393223},{"$f":"'Calculations 3'!AB12","v":5.9600868287588232E-2},{"$f":"'Calculations 3'!AC12","v":1.7412862322704562E-3},{"$f":"'Calculations 3'!AD12","v":25917.98},{"$f":"'Calculations 3'!AE12","v":2228.4299999999998},{"$f":"'Calculations 3'!AF12","v":90.48},{"$f":"'Calculations 3'!AG12","v":29674.57},{"$f":"'Calculations 3'!AH12","v":12.050458913357676},{"$f":"'Calculations 3'!AI12","v":5106.3775698032223}]
[null,null,"Genotype 2 interferon ineligible ",{"$f":"IF('Calculations 3'!V15=\"\",\"\",VLOOKUP('Calculations 3'!V15,F3_treat_duration,14,FALSE))","v":"SOF+RBV 24w"},{"$f":"IF('Calculations 3'!W15=\"\",\"\",VLOOKUP('Calculations 3'!W15,F3_treat_duration,14,FALSE))","v":""},{"$f":"IF('Calculations 3'!X15=\"\",\"\",VLOOKUP('Calculations 3'!X15,F3_treat_duration,14,FALSE))","v":""},{"$f":"'Calculations 3'!AA15","v":0.91025120817728111},{"$f":"'Calculations 3'!AB15","v":0},{"$f":"'Calculations 3'!AC15","v":0},{"$f":"'Calculations 3'!AD15","v":35340.959999999999},{"$f":"'Calculations 3'!AE15","v":0},{"$f":"'Calculations 3'!AF15","v":0},{"$f":"'Calculations 3'!AG15","v":40250.9},{"$f":"'Calculations 3'!AH15","v":11.931257805020184},{"$f":"'Calculations 3'!AI15","v":"Lowest cost"}]
[null,null,"Genotype 2 interferon eligible",{"$f":"IF('Calculations 3'!V16=\"\",\"\",VLOOKUP('Calculations 3'!V16,F3_treat_duration,14,FALSE))","v":"PR 24w"},{"$f":"IF('Calculations 3'!W16=\"\",\"\",VLOOKUP('Calculations 3'!W16,F3_treat_duration,14,FALSE))","v":"SOF+RBV 24w"},{"$f":"IF('Calculations 3'!X16=\"\",\"\",VLOOKUP('Calculations 3'!X16,F3_treat_duration,14,FALSE))","v":""},{"$f":"'Calculations 3'!AA16","v":0.77349890084413542},{"$f":"'Calculations 3'!AB16","v":0.16949954051276978},{"$f":"'Calculations 3'!AC16","v":0},{"$f":"'Calculations 3'!AD16","v":4101.5},{"$f":"'Calculations 3'!AE16","v":6731.12},{"$f":"'Calculations 3'!AF16","v":0},{"$f":"'Calculations 3'!AG16","v":14474.83},{"$f":"'Calculations 3'!AH16","v":11.919411753145216},{"$f":"'Calculations 3'!AI16","v":"Lowest cost"}]
[null,null,"Genotype 3 interferon ineligible ",{"$f":"IF('Calculations 3'!V18=\"\",\"\",VLOOKUP('Calculations 3'!V18,F3_treat_duration,14,FALSE))","v":"SOF+LED+RBV 12w"},{"$f":"IF('Calculations 3'!W18=\"\",\"\",VLOOKUP('Calculations 3'!W18,F3_treat_duration,14,FALSE))","v":"SOF+DCV 12w"},{"$f":"IF('Calculations 3'!X18=\"\",\"\",VLOOKUP('Calculations 3'!X18,F3_treat_duration,14,FALSE))","v":"SOF+RBV 24w"},{"$f":"'Calculations 3'!AA18","v":0.92428132255419326},{"$f":"'Calculations 3'!AB18","v":3.7839689233885761E-2},{"$f":"'Calculations 3'!AC18","v":2.7049620735897059E-3},{"$f":"'Calculations 3'!AD18","v":39355.31},{"$f":"'Calculations 3'!AE18","v":2510.15},{"$f":"'Calculations 3'!AF18","v":238.07},{"$f":"'Calculations 3'!AG18","v":44284.04},{"$f":"'Calculations 3'!AH18","v":11.991200969416449},{"$f":"'Calculations 3'!AI18","v":12188.552170020237}]
[null,null,"Genotype 3 interferon eligible",{"$f":"IF('Calculations 3'!V19=\"\",\"\",VLOOKUP('Calculations 3'!V19,F3_treat_duration,14,FALSE))","v":"PR 24w"},{"$f":"IF('Calculations 3'!W19=\"\",\"\",VLOOKUP('Calculations 3'!W19,F3_treat_duration,14,FALSE))","v":"SOF+PR 12w"},{"$f":"IF('Calculations 3'!X19=\"\",\"\",VLOOKUP('Calculations 3'!X19,F3_treat_duration,14,FALSE))","v":"SOF+LED+RBV 12w"},{"$f":"'Calculations 3'!AA19","v":0.66364328535652339},{"$f":"'Calculations 3'!AB19","v":0.2079105298463122},{"$f":"'Calculations 3'!AC19","v":4.7546110296117897E-2},{"$f":"'Calculations 3'!AD19","v":4099.3900000000003},{"$f":"'Calculations 3'!AE19","v":9469.67},{"$f":"'Calculations 3'!AF19","v":2201.94},{"$f":"'Calculations 3'!AG19","v":20545.39},{"$f":"'Calculations 3'!AH19","v":11.808465176589609},{"$f":"'Calculations 3'!AI19","v":"Lowest cost"}]
[null,null,"Genotype 4 interferon ineligible ",{"$f":"IF('Calculations 3'!V21=\"\",\"\",VLOOKUP('Calculations 3'!V21,F3_treat_duration,14,FALSE))","v":"2D+RBV 12w"},{"$f":"IF('Calculations 3'!W21=\"\",\"\",VLOOKUP('Calculations 3'!W21,F3_treat_duration,14,FALSE))","v":"SOF+LED 12w"},{"$f":"IF('Calculations 3'!X21=\"\",\"\",VLOOKUP('Calculations 3'!X21,F3_treat_duration,14,FALSE))","v":"SOF+DCV 12w"},{"$f":"'Calculations 3'!AA21","v":0.95215737014187274},{"$f":"'Calculations 3'!AB21","v":2.028484047101586E-2},{"$f":"'Calculations 3'!AC21","v":1.1414467368848203E-3},{"$f":"'Calculations 3'!AD21","v":32548.07},{"$f":"'Calculations 3'!AE21","v":850.97},{"$f":"'Calculations 3'!AF21","v":71.66},{"$f":"'Calculations 3'!AG21","v":35300.42},{"$f":"'Calculations 3'!AH21","v":12.018955483877505},{"$f":"'Calculations 3'!AI21","v":9485.524710453943}]
[null,null,"Genotype 4 interferon eligible",{"$f":"IF('Calculations 3'!V22=\"\",\"\",VLOOKUP('Calculations 3'!V22,F3_treat_duration,14,FALSE))","v":"PR 48w"},{"$f":"IF('Calculations 3'!W22=\"\",\"\",VLOOKUP('Calculations 3'!W22,F3_treat_duration,14,FALSE))","v":"2D+RBV 12w"},{"$f":"IF('Calculations 3'!X22=\"\",\"\",VLOOKUP('Calculations 3'!X22,F3_treat_duration,14,FALSE))","v":"SOF+LED 12w"},{"$f":"'Calculations 3'!AA22","v":0.45873492489105433},{"$f":"'Calculations 3'!AB22","v":0.42810845896261779},{"$f":"'Calculations 3'!AC22","v":7.9765315843272205E-3},{"$f":"'Calculations 3'!AD22","v":6431.08},{"$f":"'Calculations 3'!AE22","v":14319.79},{"$f":"'Calculations 3'!AF22","v":322.73},{"$f":"'Calculations 3'!AG22","v":28099.49},{"$f":"'Calculations 3'!AH22","v":11.713465971729942},{"$f":"'Calculations 3'!AI22","v":"Lowest cost"}]
[]
[null,null,"PR: pegylated interferon with ribavirin. SMV+PR: simeprevir with pegylated interferon and ribavirin. SOF+PR: sofosbuvir with pegylated interferon with ribavirin. SOF+LED: sofosbuvir with ledipasvir. \nSOF+LED+RBV: sofosbuvir with ledipasvir and ribavirin. 3D+/-RBV: ombitasvir with paritaprevir with ritonavir and dasabuvir with or without ribavirin. \n2D+RBV: ombitasvir with paritaprevir with ritonavir and ribavirin. SOF+DCV: sofosbuvir with daclatasvir. DCV+PR: daclatasvir with pegylated interferon and ribavirin."]
[null,null,"Treatment duration is indicated in weeks. For example, SOF+LED 8w refers to a treatment over 8 weeks. "]
[]
[null,null,"Treatment-experienced patients"]
[]
[null,null,null,"Cost-effective strategies",null,null,"% Patients achieving SVR by line",null,null,"Treatment cost by line",null,null,"Total","Total","ICER"]
[null,null,"Subgroup","1st line","2nd line","3rd line","1st ","2nd ","3rd ","1st ","2nd ","3rd ","Costs","QALYs "]
[null,null,"Genotype 1 experienced to interferon ",{"$f":"IF('Calculations 3'!V13=\"\",\"\",VLOOKUP('Calculations 3'!V13,F3_treat_duration,14,FALSE))","v":"PR 48w"},{"$f":"IF('Calculations 3'!W13=\"\",\"\",VLOOKUP('Calculations 3'!W13,F3_treat_duration,14,FALSE))","v":"3D+/-RBV 12w"},{"$f":"IF('Calculations 3'!X13=\"\",\"\",VLOOKUP('Calculations 3'!X13,F3_treat_duration,14,FALSE))","v":"SOF+LED 12w"},{"$f":"'Calculations 3'!AA13","v":0.40502478376210033},{"$f":"'Calculations 3'!AB13","v":0.46998102456121843},{"$f":"'Calculations 3'!AC13","v":1.7755117074518736E-2},{"$f":"'Calculations 3'!AD13","v":6109.6},{"$f":"'Calculations 3'!AE13","v":17067.96},{"$f":"'Calculations 3'!AF13","v":719.3},{"$f":"'Calculations 3'!AG13","v":31011.31},{"$f":"'Calculations 3'!AH13","v":11.717072572987913},{"$f":"'Calculations 3'!AI13","v":"Lowest cost"}]
[null,null,"Genotype 1 experienced to protease inhibitors ",{"$f":"IF('Calculations 3'!V14=\"\",\"\",VLOOKUP('Calculations 3'!V14,F3_treat_duration,14,FALSE))","v":"SMV+PR 12+24w"},{"$f":"IF('Calculations 3'!W14=\"\",\"\",VLOOKUP('Calculations 3'!W14,F3_treat_duration,14,FALSE))","v":"3D+/-RBV 12w"},{"$f":"IF('Calculations 3'!X14=\"\",\"\",VLOOKUP('Calculations 3'!X14,F3_treat_duration,14,FALSE))","v":"SOF+LED 12w"},{"$f":"'Calculations 3'!AA14","v":0.7553083472103661},{"$f":"'Calculations 3'!AB14","v":0.18256591315074505},{"$f":"'Calculations 3'!AC14","v":6.8945470139136359E-3},{"$f":"'Calculations 3'!AD14","v":25929.42},{"$f":"'Calculations 3'!AE14","v":6745.58},{"$f":"'Calculations 3'!AF14","v":284.16000000000003},{"$f":"'Calculations 3'!AG14","v":36397.040000000001},{"$f":"'Calculations 3'!AH14","v":11.900991752062538},{"$f":"'Calculations 3'!AI14","v":"Lowest cost"}]
[null,null,"Genotype 2 experienced to interferon",{"$f":"IF('Calculations 3'!V17=\"\",\"\",VLOOKUP('Calculations 3'!V17,F3_treat_duration,14,FALSE))","v":"PR 24w"},{"$f":"IF('Calculations 3'!W17=\"\",\"\",VLOOKUP('Calculations 3'!W17,F3_treat_duration,14,FALSE))","v":"SOF+RBV 24w"},{"$f":"IF('Calculations 3'!X17=\"\",\"\",VLOOKUP('Calculations 3'!X17,F3_treat_duration,14,FALSE))","v":""},{"$f":"'Calculations 3'!AA17","v":0.77349890084413542},{"$f":"'Calculations 3'!AB17","v":0.16949954051276978},{"$f":"'Calculations 3'!AC17","v":0},{"$f":"'Calculations 3'!AD17","v":4101.5},{"$f":"'Calculations 3'!AE17","v":6731.12},{"$f":"'Calculations 3'!AF17","v":0},{"$f":"'Calculations 3'!AG17","v":14474.83},{"$f":"'Calculations 3'!AH17","v":11.919411753145216},{"$f":"'Calculations 3'!AI17","v":"Lowest cost"}]
[null,null,"Genotype 3 experienced to interferon ",{"$f":"IF('Calculations 3'!V20=\"\",\"\",VLOOKUP('Calculations 3'!V20,F3_treat_duration,14,FALSE))","v":"PR 24w"},{"$f":"IF('Calculations 3'!W20=\"\",\"\",VLOOKUP('Calculations 3'!W20,F3_treat_duration,14,FALSE))","v":"SOF+PR 12w"},{"$f":"IF('Calculations 3'!X20=\"\",\"\",VLOOKUP('Calculations 3'!X20,F3_treat_duration,14,FALSE))","v":"SOF+LED+RBV 12w"},{"$f":"'Calculations 3'!AA20","v":0.66364328535652339},{"$f":"'Calculations 3'!AB20","v":0.2079105298463122},{"$f":"'Calculations 3'!AC20","v":4.7546110296117897E-2},{"$f":"'Calculations 3'!AD20","v":4099.3900000000003},{"$f":"'Calculations 3'!AE20","v":9469.67},{"$f":"'Calculations 3'!AF20","v":2201.94},{"$f":"'Calculations 3'!AG20","v":20545.39},{"$f":"'Calculations 3'!AH20","v":11.808465176589609},{"$f":"'Calculations 3'!AI20","v":"Lowest cost"}]
[null,null,"Genotype 4 experienced to interferon ",{"$f":"IF('Calculations 3'!V23=\"\",\"\",VLOOKUP('Calculations 3'!V23,F3_treat_duration,14,FALSE))","v":"PR 48w"},{"$f":"IF('Calculations 3'!W23=\"\",\"\",VLOOKUP('Calculations 3'!W23,F3_treat_duration,14,FALSE))","v":"2D+RBV 12w"},{"$f":"IF('Calculations 3'!X23=\"\",\"\",VLOOKUP('Calculations 3'!X23,F3_treat_duration,14,FALSE))","v":"SOF+LED 12w"},{"$f":"'Calculations 3'!AA23","v":0.45873492489105433},{"$f":"'Calculations 3'!AB23","v":0.42810845896261779},{"$f":"'Calculations 3'!AC23","v":7.9765315843272205E-3},{"$f":"'Calculations 3'!AD23","v":6431.08},{"$f":"'Calculations 3'!AE23","v":14319.79},{"$f":"'Calculations 3'!AF23","v":322.73},{"$f":"'Calculations 3'!AG23","v":28099.49},{"$f":"'Calculations 3'!AH23","v":11.713465971729942},{"$f":"'Calculations 3'!AI23","v":"Lowest cost"}]
[null,null,"Genotype 4 experienced to protease inhibitors ",{"$f":"IF('Calculations 3'!V24=\"\",\"\",VLOOKUP('Calculations 3'!V24,F3_treat_duration,14,FALSE))","v":"SMV+PR 12+24w"},{"$f":"IF('Calculations 3'!W24=\"\",\"\",VLOOKUP('Calculations 3'!W24,F3_treat_duration,14,FALSE))","v":"2D+RBV 12w"},{"$f":"IF('Calculations 3'!X24=\"\",\"\",VLOOKUP('Calculations 3'!X24,F3_treat_duration,14,FALSE))","v":"SOF+LED 12w"},{"$f":"'Calculations 3'!AA24","v":0.78208735587213019},{"$f":"'Calculations 3'!AB24","v":0.16069492821466222},{"$f":"'Calculations 3'!AC24","v":2.9619949963033613E-3},{"$f":"'Calculations 3'!AD24","v":25506.79},{"$f":"'Calculations 3'!AE24","v":5467.78},{"$f":"'Calculations 3'!AF24","v":121.92},{"$f":"'Calculations 3'!AG24","v":34441.14},{"$f":"'Calculations 3'!AH24","v":11.903250181601107},{"$f":"'Calculations 3'!AI24","v":"Lowest cost"}]

{"sheet":"Calculations 1","index":3,"n_rows":210,"n_cols":19,"rows_kept":210,"cut":false,"hidden":true,"merged":[[12,9,12,11],[43,16,43,18],[43,4,43,5],[43,10,43,11],[43,12,43,14],[12,3,12,5]]}
[]
[]
[null,null,"Background calculations - part 1"]
[]
[null,null,"This sheet calculates the cost of treatment at the F3 stage, cirrhosis and decompensated cirrhosis using list prices and discounted prices. "]
[]
[]
[]
[null,null,"Costs of treatment at the F3 stage"]
[]
[null,null,"This section calculates the duration of treatment accounting for discontinuations and the cost of treatment under list prices and discounted prices."]
[]
[null,null,null,"List prices",null,null,null,null,null,"Current prices"]
[null,null,"Medication (abbreviated name)","cost 12 weeks","cost/week","unit cost","size","dose","new prices per pack","Current prices","Current prices/week","Over 12 weeks"]
[null,null,"SOF",{"$f":"E15*12","v":34982.94},{"$f":"F15/4","v":2915.2449999999999},11660.98,28,1,{"$f":"IF(sofnew=\"\",IF(sofdis=\"\",\"\",(1-sofdis)*soflist),sofnew)","v":""},{"$f":"IF(I15=\"\",F15,I15)","v":11660.98},{"$f":"J15/G15*H15*7","v":2915.2449999999999},{"$f":"K15*12","v":34982.94}]
[null,null,"SMV",22398,{"$f":"F16","v":1866.5},1866.5,7,1,{"$f":"IF(simnew=\"\",IF(simdis=\"\",\"\",(1-simdis)*simlist),simnew)","v":""},{"$f":"IF(I16=\"\",F16,I16)","v":1866.5},{"$f":"J16/G16*H16*7","v":1866.5000000000002},{"$f":"K16*12","v":22398.000000000004}]
[null,null,"P",1488,{"$f":"F17","v":124},124,1,{"$f":"1/7","v":0.14285714285714285},{"$f":"IF(prnew=\"\",IF(prdis=\"\",\"\",(1-prdis)*prlist),prnew)","v":""},124,123.99999999999999,1487.9999999999998]
[null,null,"RBV",964.14,{"$f":"(F18/(G18/H18))*7","v":80.344999999999999},321.38,168,{"$f":"1200/200","v":6},{"$f":"IF(ribnew=\"\",IF(ribdis=\"\",\"\",(1-ribdis)*riblist),ribnew)","v":""},321.38,80.344999999999999,964.14]
[null,null,"PR",2452.14,{"$f":"E17+E18","v":204.345},"N/A","N/A","N/A","N/A",null,{"$f":"K18+K17","v":204.34499999999997},2452.1399999999994]
[null,null,"SOF+LED",38979.99,{"$f":"F20/4","v":3248.3325},12993.33,28,1,{"$f":"IF(soflednew=\"\",IF(sofleddis=\"\",\"\",(1-sofleddis)*sofledlist),soflednew)","v":""},12993.33,3248.3325,38979.99]
[null,null,"SOF+LED+R",39944.129999999997,{"$f":"E20+E18","v":3328.6774999999998},"N/A","N/A","N/A","N/A","N/A",{"$f":"K20+K18","v":3328.6774999999998},39944.129999999997]
[null,null,"SOF+PR",37435.079999999994,{"$f":"E15+E19","v":3119.5899999999997},"N/A","N/A","N/A","N/A","N/A",{"$f":"K15+K18+K17","v":3119.5899999999997},37435.079999999994]
[null,null,"SOF+RBV",35947.079999999994,{"$f":"E15+E18","v":2995.5899999999997},"N/A","N/A","N/A","N/A","N/A",{"$f":"K15+K18","v":2995.5899999999997},35947.079999999994]
[null,null,"SMV+PR",{"$f":"D16+E19*24","v":27302.28},{"$f":"E16+E19","v":2070.8449999999998},"N/A","N/A","N/A","N/A","N/A","N/A",{"$f":"K19*24+K16*12","v":27302.280000000002}]
[null,null,"DCV",{"$f":"E25*12","v":24516},2043,{"$f":"E25/7*G25","v":8171.9999999999991},28,1,{"$f":"IF(dacnew=\"\",IF(dacdis=\"\",\"\",(1-dacdis)*daclist),dacnew)","v":""},8171.9999999999991,2042.9999999999998,24515.999999999996]
[null,null,"SOF+DCV",{"$f":"D15+D25","v":59498.94},{"$f":"E25+E15","v":4958.2449999999999},"N/A","N/A","N/A","N/A","N/A",{"$f":"K25+K15","v":4958.2449999999999},59498.94]
[null,null,"SOF+DCV+R",{"$f":"D26+D18","v":60463.08},{"$f":"E26+E18","v":5038.59},"N/A","N/A","N/A","N/A","N/A",{"$f":"K26+K18","v":5038.59},60463.08]
[null,null,"2D",{"$f":"E28*12","v":32199.989999999998},{"$f":"F28/4","v":2683.3325},10733.33,56,2,{"$f":"IF(new3d=\"\",IF(dis3d=\"\",\"\",(1-dis3d)*list3d),new3d)","v":""},10733.33,2683.3325,32199.989999999998]
[null,null,"2D+R",{"$f":"E29*12","v":33164.129999999997},{"$f":"E28+E18","v":2763.6774999999998},"N/A","N/A","N/A","N/A","N/A",{"$f":"K28+K18","v":2763.6774999999998},33164.129999999997]
[null,null,"3D",{"$f":"E30*12","v":34998.99},{"$f":"(F28+F33)/4","v":2916.5825},"N/A","N/A","N/A","N/A","N/A",{"$f":"K28+K33","v":2916.5825},34998.99]
[null,null,"3D+R",{"$f":"E31*12","v":35963.129999999997},{"$f":"E30+E18","v":2996.9274999999998},"N/A","N/A","N/A","N/A","N/A",{"$f":"K30+K18","v":2996.9274999999998},35963.129999999997]
[null,null,"3D+/-R",{"$f":"E32*12","v":35664.246599999999},{"$f":"E31*prob_G1a+E30*(1-prob_G1a)","v":2972.0205500000002},"N/A","N/A","N/A","N/A","N/A",{"$f":"K31*prob_G1a+K30*(1-prob_G1a)","v":2972.0205500000002},35664.246599999999]
[null,null,"Dasabuvir","N/A","N/A",933,56,2,{"$f":"IF(dasnew=\"\",IF(dasdis=\"\",\"\",(1-dasdis)*daslist),dasnew)","v":""},933,233.25,2799]
[]
[]
[null,null,"prob_G1a",0.69,"Proportion of individuals infected with HCV genotype 1 who have subtype 1a"]
[]
[]
[null,null,"Calculation of treatment duration and costs"]
[]
[null,null,"This section calculated the cost of treatment given the discounted prices and accounting for discontinuations."]
[]
[null,null,null,null,null,"Weeks:",4,12,24,36]
[null,null,null,null,null,null,null,null,null,null,"Duration in the model",null,"Costs based on list prices",null,null,null,"Costs based on current prices"]
[null,null,"Strategy: model name","Regimen (abbreviated)","Duration SPC 1","Duration SPC 2","Disc w4","Disc w12","Disc w24","Disc w36","Duration (1)","Duration (2)","Treatment (1)","Treatment (2)","Total","Names","Treatment 1","Treatment 2","Total"]
[null,null,"NT","NT",0,0,0,0,0,null,0,0,0,0,{"$f":"SUM(M46:N46)","v":0},"Watchful waiting",0,0,{"$f":"Q46+R46","v":0}]
[null,null,"G1_TN IE_PR48","PR",48,0,0.17414122137404581,6.7907124681933842E-2,0.29672068400396773,6.7907124681933842E-2,{"$f":"G47*$G$43+H47*$H$43+I47*$I$43+J47*$J$43+(1-SUM(G47:J47))*E47","v":29.956947858713939},{"$f":"IF(F47=0,0,G47*$G$43+H47*$H$43+I47*$I$43+J47*$J$43+(1-SUM(G47:J47))*F47)","v":0},{"$f":"K47*IF(D47=\"SMV+PR\",$E$16,IF(D47=\"DCV+PR\",$E$25,VLOOKUP(D47,$C$15:$E$32,3,FALSE)))","v":6121.5525101888998},{"$f":"L47*$E$19","v":0},{"$f":"SUM(M47:N47)","v":6121.5525101888998},"PR 48w",{"$f":"K47*IF(D47=\"SMV+PR\",$K$16,IF(D47=\"DCV+PR\",$K$25,VLOOKUP(D47,$C$15:$L$33,9,FALSE)))","v":6121.5525101888989},{"$f":"L47*$K$19","v":0},{"$f":"Q47+R47","v":6121.5525101888989}]
[null,null,"G1_TE IE_PR48","PR",48,0,0.11363636363636363,0.16919191919191917,0.16919191919191917,0.16919191919191917,30.81818181818182,0,6297.5413636363637,0,{"$f":"SUM(M48:N48)","v":6297.5413636363637},"PR 48w",{"$f":"K48*IF(D48=\"SMV+PR\",$K$16,IF(D48=\"DCV+PR\",$K$25,VLOOKUP(D48,$C$15:$L$33,9,FALSE)))","v":6297.5413636363628},{"$f":"L48*$K$19","v":0},6297.5413636363628]
[null,null,"G2_TN IE_PR24","PR",24,0,0.15226337448559671,6.9958847736625515E-2,0,0,20.115226337448561,0,4110.4459259259265,0,4110.4459259259265,"PR 24w",4110.4459259259256,0,4110.4459259259256]
[null,null,"G2_TE IE_PR48","PR",48,0,0.40677966101694918,0,0,0,30.101694915254235,0,6151.1308474576263,0,6151.1308474576263,"PR 48w",6151.1308474576263,0,6151.1308474576263]
[null,null,"G3_TN IE_PR24","PR",24,0,0.15226337448559671,6.9958847736625515E-2,0,0,20.115226337448561,0,4110.4459259259265,0,4110.4459259259265,"PR 24w",4110.4459259259256,0,4110.4459259259256]
[null,null,"G3_TE IE_PR48","PR",48,0,8.8989441930618404E-2,0.19867549668874171,0.19867549668874171,0.19867549668874171,29.779828793463388,0,6085.3591148002761,0,6085.3591148002761,"PR 48w",6085.3591148002752,0,6085.3591148002752]
[null,null,"G4_TN IE_PR48","PR",48,0,0.13940256045519203,3.1077694235588975E-2,0.3644110275689223,3.1077694235588975E-2,31.628693355009148,0,6463.1653436293445,0,6463.1653436293445,"PR 48w",6463.1653436293436,0,6463.1653436293436]
[null,null,"G4_TE IE_PR48","PR",48,0,5.6291390728476824E-2,0.19867549668874171,0.19867549668874171,0.19867549668874171,31.218543046357617,0,6379.3531788079472,0,6379.3531788079472,"PR 48w",6379.3531788079463,0,6379.3531788079463]
[null,null,"G1_TN IE_SMV+PR12+24","SMV+PR",12,24,6.5938750689859563E-2,2.0500000000000001E-2,0,0,11.472489994481123,22.435224986202808,21413.402574699016,4584.5260498056132,25997.928624504628,"SMV+PR 12+24w",21413.402574699019,4584.5260498056123,25997.928624504631]
[null,null,"G1_TE IE_SMV+PR12+48","SMV+PR",12,48,6.2710784313725482E-2,3.1460784313725489E-2,0.5510686274509804,0,18.111137254901962,30.882490196078436,33804.437686274512,6310.6824591176482,40115.12014539216,"SMV+PR 12+48w",33804.437686274519,6310.6824591176473,40115.120145392168]
[null,null,"G4_TN IE_SMV+PR12+24","SMV+PR",12,24,8.5714285714285715E-2,2.8571428571428571E-2,0,0,11.314285714285713,21.942857142857143,21118.114285714284,4483.9131428571427,25602.027428571426,"SMV+PR 12+24w",21118.114285714288,4483.9131428571427,25602.027428571429]
[null,null,"G4_TE IE_SMV+PR12+48","SMV+PR",12,48,9.7222222222222224E-2,6.9444444444444448E-2,0.375,0,15.722222222222221,32.222222222222214,29345.527777777777,6584.449999999998,35929.977777777778,"SMV+PR 12+48w",29345.527777777781,6584.4499999999971,35929.977777777778]
[null,null,"G1_TN IE_SOF+LED8","SOF+LED",8,0,0,0,0,0,8,0,25986.66,0,25986.66,"SOF+LED 8w",25986.66,0,25986.66]
[null,null,"G1_TN III_SOF+LED8","SOF+LED",8,0,0,0,0,0,8,0,25986.66,0,25986.66,"SOF+LED 8w",25986.66,0,25986.66]
[null,null,"G1_TE IE_SOF+LED12","SOF+LED",12,0,0,0,0,0,12,0,38979.99,0,38979.99,"SOF+LED 12w",38979.99,0,38979.99]
[null,null,"G1_TE III_SOF+LED12","SOF+LED",12,0,0,0,0,0,12,0,38979.99,0,38979.99,"SOF+LED 12w",38979.99,0,38979.99]
[null,null,"G4_TN IE_SOF+LED12","SOF+LED",12,0,1.627906976744186E-2,0,0,0,11.869767441860466,0,38556.95134883721,0,38556.95134883721,"SOF+LED 12w",38556.95134883721,0,38556.95134883721]
[null,null,"G4_TN III_SOF+LED12","SOF+LED",12,0,1.627906976744186E-2,0,0,0,11.869767441860466,0,38556.95134883721,0,38556.95134883721,"SOF+LED 12w",38556.95134883721,0,38556.95134883721]
[null,null,"G4_TE IE_SOF+LED12","SOF+LED",12,0,0,0,0,0,12,0,38979.99,0,38979.99,"SOF+LED 12w",38979.99,0,38979.99]
[null,null,"G4_TE III_SOF+LED12","SOF+LED",12,0,0,0,0,0,12,0,38979.99,0,38979.99,"SOF+LED 12w",38979.99,0,38979.99]
[null,null,"G3_TN IE_SOF+LED+R12","SOF+LED+R",12,0,1.8433179723502304E-2,0,0,0,11.85253456221198,0,39453.265115207367,0,39453.265115207367,"SOF+LED+RBV 12w",39453.265115207367,0,39453.265115207367]
[null,null,"G3_TN III_SOF+LED+R12","SOF+LED+R",12,0,1.8433179723502304E-2,0,0,0,11.85253456221198,0,39453.265115207367,0,39453.265115207367,"SOF+LED+RBV 12w",39453.265115207367,0,39453.265115207367]
[null,null,"G3_TE IE_SOF+LED+R12","SOF+LED+R",12,0,0,0,0,0,12,0,39944.129999999997,0,39944.129999999997,"SOF+LED+RBV 12w",39944.129999999997,0,39944.129999999997]
[null,null,"G3_TE III_SOF+LED+R12","SOF+LED+R",12,0,0,0,0,0,12,0,39944.129999999997,0,39944.129999999997,"SOF+LED+RBV 12w",39944.129999999997,0,39944.129999999997]
[null,null,"G1_TN IE_SOF+PR12","SOF+PR",12,0,2.1406727828746176E-2,0,0,0,11.82874617737003,0,36900.838287461767,0,36900.838287461767,"SOF+PR 12w",36900.838287461767,0,36900.838287461767]
[null,null,"G1_TE IE_SOF+PR12","SOF+PR",12,0,0,0,0,0,12,0,37435.079999999994,0,37435.079999999994,"SOF+PR 12w",37435.079999999994,0,37435.079999999994]
[null,null,"G3_TN IE_SOF+PR12","SOF+PR",12,0,3.125E-2,0,0,0,11.75,0,36655.182499999995,0,36655.182499999995,"SOF+PR 12w",36655.182499999995,0,36655.182499999995]
[null,null,"G3_TE IE_SOF+PR12","SOF+PR",12,0,8.3333333333333329E-2,0,0,0,11.333333333333334,0,35355.353333333333,0,35355.353333333333,"SOF+PR 12w",35355.353333333333,0,35355.353333333333]
[null,null,"G4_TE IE_SOF+PR12","SOF+PR",12,0,0,0,0,0,12,0,37435.079999999994,0,37435.079999999994,"SOF+PR 12w",37435.079999999994,0,37435.079999999994]
[null,null,"G4_TN IE_SOF+PR12","SOF+PR",12,0,2.1406727828746176E-2,0,0,0,11.82874617737003,0,36900.838287461767,0,36900.838287461767,"SOF+PR 12w",36900.838287461767,0,36900.838287461767]
[null,null,"G1_TN III_SOF+RBV24","SOF+RBV",24,0,0.1,0,0,0,22,0,65902.98,0,65902.98,"SOF+RBV 24w",65902.98,0,65902.98]
[null,null,"G1_TE III_SOF+RBV24","SOF+RBV",24,0,0.1,0,0,0,22,0,65902.98,0,65902.98,"SOF+RBV 24w",65902.98,0,65902.98]
[null,null,"G2_TN IE_SOF+RBV12","SOF+RBV",12,0,3.3434650455927049E-2,0,0,0,{"$f":"G79*$G$43+H79*$H$43+I79*$I$43+J79*$J$43+(1-SUM(G79:J79))*E79","v":11.732522796352583},{"$f":"IF(F79=0,0,G79*$G$43+H79*$H$43+I79*$I$43+J79*$J$43+(1-SUM(G79:J79))*F79)","v":0},{"$f":"K79*IF(D79=\"SMV+PR\",$E$16,IF(D79=\"DCV+PR\",$E$25,VLOOKUP(D79,$C$15:$E$32,3,FALSE)))","v":35145.82796352583},{"$f":"L79*$E$19","v":0},35145.82796352583,"SOF+RBV 24w",35145.82796352583,0,35145.82796352583]
[null,null,"G2_TN III_SOF+RBV12","SOF+RBV",12,0,2.1428571428571429E-2,0,0,0,11.828571428571427,0,35433.550285714278,0,35433.550285714278,"SOF+RBV 24w",35433.550285714278,0,35433.550285714278]
[null,null,"G2_TE IE_SOF+RBV12","SOF+RBV",12,0,5.681818181818182E-3,0,0,0,11.954545454545455,0,35810.916818181817,0,35810.916818181817,"SOF+RBV 24w",35810.916818181817,0,35810.916818181817]
[null,null,"G2_TE III_SOF+RBV12","SOF+RBV",12,0,2.1428571428571429E-2,0,0,0,11.828571428571427,0,35433.550285714278,0,35433.550285714278,"SOF+RBV 24w",35433.550285714278,0,35433.550285714278]
[null,null,"G3_TN IE_SOF+RBV24","SOF+RBV",24,0,1.6E-2,0,0,0,23.68,0,70935.571199999991,0,70935.571199999991,"SOF+RBV 24w",70935.571199999991,0,70935.571199999991]
[null,null,"G3_TE IE_SOF+RBV24","SOF+RBV",24,0,1.6E-2,0,0,0,23.68,0,70935.571199999991,0,70935.571199999991,"SOF+RBV 24w",70935.571199999991,0,70935.571199999991]
[null,null,"G3_TN III_SOF+RBV24","SOF+RBV",24,0,1.6E-2,0,0,0,23.68,0,70935.571199999991,0,70935.571199999991,"SOF+RBV 24w",70935.571199999991,0,70935.571199999991]
[null,null,"G3_TE III_SOF+RBV24","SOF+RBV",24,0,1.6E-2,0,0,0,23.68,0,70935.571199999991,0,70935.571199999991,"SOF+RBV 24w",70935.571199999991,0,70935.571199999991]
[null,null,"G4_TN III_SOF+RBV24","SOF+RBV",24,0,0.05,0,0,0,22.999999999999996,0,68898.569999999978,0,68898.569999999978,"SOF+RBV 24w",68898.569999999978,0,68898.569999999978]
[null,null,"G4_TE III_SOF+RBV24","SOF+RBV",24,0,0.05,0,0,0,22.999999999999996,0,68898.569999999978,0,68898.569999999978,"SOF+RBV 24w",68898.569999999978,0,68898.569999999978]
[null,null,"G1_TN IE_3D+/-R12","3D+/-R",12,0,1.4168984700973575E-2,0,0,0,11.886648122392211,0,35327.36249036857,0,35327.36249036857,"3D+/-RBV 12w",35327.36249036857,0,35327.36249036857]
[null,null,"G1_TN III_3D+/-R12","3D+/-R",12,0,1.4168984700973575E-2,0,0,0,11.886648122392211,0,35327.36249036857,0,35327.36249036857,"3D+/-RBV 12w",35327.36249036857,0,35327.36249036857]
[null,null,"G1_TE IE_3D+/-R12","3D+/-R",12,0,1.6042324430412151E-2,0,0,0,11.871661404556701,0,35282.821656984379,0,{"$f":"SUM(M91:N91)","v":35282.821656984379},"3D+/-RBV 12w",35282.821656984379,0,35282.821656984379]
[null,null,"G1_TE III_3D+/-R12","3D+/-R",12,0,1.6042324430412151E-2,0,0,0,11.871661404556701,0,35282.821656984379,0,35282.821656984379,"3D+/-RBV 12w",35282.821656984379,0,35282.821656984379]
[null,null,"G4_TN IE_2D+R12","2D+R",12,0,2.3809523809523808E-2,0,0,0,11.809523809523808,0,32637.715238095232,0,32637.715238095232,"2D+RBV 12w",32637.715238095232,0,32637.715238095232]
[null,null,"G4_TN III_2D+R12","2D+R",12,0,2.3809523809523808E-2,0,0,0,11.809523809523808,0,32637.715238095232,0,32637.715238095232,"2D+RBV 12w",32637.715238095232,0,32637.715238095232]
[null,null,"G4_TE IE_2D+R12","2D+R",12,0,0,0,0,0,12,0,33164.129999999997,0,33164.129999999997,"2D+RBV 12w",33164.129999999997,0,33164.129999999997]
[null,null,"G4_TE III_2D+R12","2D+R",12,0,0,0,0,0,12,0,33164.129999999997,0,33164.129999999997,"2D+RBV 12w",33164.129999999997,0,33164.129999999997]
[null,null,"G1_TN IE_SOF+DCV12","SOF+DCV",12,0,5.0000000000000001E-3,0,0,0,11.959999999999999,0,59300.610199999996,0,{"$f":"SUM(M97:N97)","v":59300.610199999996},"SOF+DCV 12w",59300.610199999996,0,59300.610199999996]
[null,null,"G1_TN III_SOF+DCV12","SOF+DCV",12,0,5.0000000000000001E-3,0,0,0,11.959999999999999,0,59300.610199999996,0,{"$f":"SUM(M98:N98)","v":59300.610199999996},"SOF+DCV 12w",59300.610199999996,0,59300.610199999996]
[null,null,"G1_TE IE_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,{"$f":"SUM(M99:N99)","v":59498.94},"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G1_TE III_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,59498.94,"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G3_TN IE_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,59498.94,"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G3_TN III_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,59498.94,"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G3_TE IE_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,59498.94,"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G3_TE III_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,59498.94,"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G4_TN IE_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,59498.94,"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G4_TN III_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,59498.94,"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G4_TE IE_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,59498.94,"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G4_TE III_SOF+DCV12","SOF+DCV",12,0,0,0,0,0,12,0,59498.94,0,59498.94,"SOF+DCV 12w",59498.94,0,59498.94]
[null,null,"G4_TN IE_DCV+PR24+48","DCV+PR",24,48,0.183,0,0.67,0,20.340000000000003,23.868000000000002,41554.62000000001,4877.3064600000007,46431.92646000001,"DCV+PR 24+48w",41554.620000000003,4877.3064599999998,46431.926460000002]
[null,null,"G4_TE IE_DCV+PR24+48","DCV+PR",24,48,0.183,0,0.67,0,20.340000000000003,23.868000000000002,41554.62000000001,4877.3064600000007,46431.92646000001,"DCV+PR 24+48w",41554.620000000003,4877.3064599999998,46431.926460000002]
[]
[]
[]
[null,null,"Costs of treatment in cirrhotic patients"]
[]
[null,null,"This section calculates the cost of treatment in patients with cirrhosis. "]
[null,null,"Treatment is modelled as a composite strategy, in which the recommended treatments by NHS England's commissioning policy are used equally."]
[null,null,"Therefore, its costs and effectiveness corresponds to the average of the individual treatments' cost and effectiveness. "]
[null,null,"Treatment is assumed to have two lines, hence patients who fail the first treatment are retreated. "]
[]
[null,null,"Treatment strategy by subgroup","Cost pre-discount","Cost post discount"]
[null,null,"G1 TN IE_F4SVR",{"$f":"(F$138+(1-$E$138)*F$143)","v":38934.469518204533},{"$f":"(G$138+(1-$E$138)*G$143)","v":38934.469518204533}]
[null,null,"G1 TN III_F4SVR",{"$f":"(F$148+(1-$E$148)*F$152)","v":39751.169538303686},{"$f":"(G$148+(1-$E$148)*G$152)","v":39751.169538303686}]
[null,null,"G3 TN IE_F4SVR",{"$f":"(F$155+(1-$E$155)*F$158)","v":43674.259999999995},{"$f":"(G$155+(1-$E$155)*G$158)","v":43674.259999999995}]
[null,null,"G3 TN III_F4SVR",{"$f":"(F$161+(1-$E$161)*F$165)","v":60772.784999999996},{"$f":"(G$161+(1-$E$161)*G$165)","v":60772.784999999996}]
[null,null,"G4 TN IE_F4SVR",{"$f":"(F$169+(1-$E$169)*F$173)","v":39639.396764705874},{"$f":"(G$169+(1-$E$169)*G$173)","v":39639.396764705882}]
[null,null,"G4 TN III_F4SVR",{"$f":"(F$177+(1-$E$177)*F$180)","v":41272.930588235293},{"$f":"(G$177+(1-$E$177)*G$180)","v":41272.930588235293}]
[null,null,"G1 TE IE_F4SVR",{"$f":"(F$143+(1-$E$143)*F$143)","v":42608.781603723226},{"$f":"(G$143+(1-$E$143)*G$143)","v":42608.781603723226}]
[null,null,"G1 TE III_F4SVR",{"$f":"(F$152+(1-$E$152)*F$152)","v":43554.765279433675},{"$f":"(G$152+(1-$E$152)*G$152)","v":43554.765279433675}]
[null,null,"G3 TE IE_F4SVR",{"$f":"(F$158+(1-$E$158)*F$158)","v":43674.259999999995},{"$f":"(G$158+(1-$E$158)*G$158)","v":43674.259999999995}]
[null,null,"G3 TE III_F4SVR",{"$f":"(F$165+(1-$E$165)*F$165)","v":63632.191652097899},{"$f":"(G$165+(1-$E$165)*G$165)","v":63632.191652097899}]
[null,null,"G4 TE IE_F4SVR",{"$f":"(F$173+(1-$E$173)*F$173)","v":45487.190232213426},{"$f":"(G$173+(1-$E$173)*G$173)","v":45487.190232213441}]
[null,null,"G4 TE III_F4SVR",{"$f":"(F$180+(1-$E$180)*F$180)","v":44295.443181818177},{"$f":"(G$180+(1-$E$180)*G$180)","v":44295.443181818177}]
[]
[]
[null,null,"Calculation of cost of the composite treatment in cirrhotic patients"]
[null,null,"G1 TN IE","Regimen","SVR% Live","Cost pre-discount","Cost post discount"]
[null,null,"Weighted",null,0.85761698272378395,{"$f":"AVERAGE(F139:F141)","v":34081.799999999996},{"$f":"AVERAGE(G139:G141)","v":34081.799999999996}]
[null,null,"SMV+PR","G1 TN IE_SMV+PR",0.68981401246683749,{"$f":"VLOOKUP(C139,cost12w,2,FALSE)","v":27302.28},{"$f":"VLOOKUP(C139,cost12w,10,FALSE)","v":27302.280000000002}]
[null,null,"SOF+LED","G1 TN IE_SOF+LED",0.94117647058823528,{"$f":"VLOOKUP(C140,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C140,cost12w,10,FALSE)","v":38979.99}]
[null,null,"3D+R","G1 TN IE_3D+R",0.94186046511627908,{"$f":"VLOOKUP(C141,cost12w,2,FALSE)","v":35963.129999999997},{"$f":"VLOOKUP(C141,cost12w,10,FALSE)","v":35963.129999999997}]
[null,null,"G1 TE IE"]
[null,null,"Weighted",null,0.74980835508326349,{"$f":"AVERAGE(F144:F146)","v":34081.799999999996},{"$f":"AVERAGE(G144:G146)","v":34081.799999999996}]
[null,null,"SMV+PR","G1 TE IE_SMV+PR",0.48414935735113196,{"$f":"VLOOKUP(C144,cost12w,2,FALSE)","v":27302.28},{"$f":"VLOOKUP(C144,cost12w,10,FALSE)","v":27302.280000000002}]
[null,null,"SOF+LED","G1 TE IE_SOF+LED",0.86363636363636365,{"$f":"VLOOKUP(C145,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C145,cost12w,10,FALSE)","v":38979.99}]
[null,null,"3D+R","G1 TE IE_3D+R",0.90163934426229508,{"$f":"VLOOKUP(C146,cost12w,2,FALSE)","v":35963.129999999997},{"$f":"VLOOKUP(C146,cost12w,10,FALSE)","v":35963.129999999997}]
[null,null,"G1 TN III"]
[null,null,"Weighted",null,0.94151846785225723,{"$f":"AVERAGE(F149:F150)","v":37471.56},{"$f":"AVERAGE(G149:G150)","v":37471.56}]
[null,null,"SOF+LED","G1 TN III_SOF+LED",0.94117647058823528,{"$f":"VLOOKUP(C149,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C149,cost12w,10,FALSE)","v":38979.99}]
[null,null,"3D+R","G1 TN III_3D+R",0.94186046511627908,{"$f":"VLOOKUP(C150,cost12w,2,FALSE)","v":35963.129999999997},{"$f":"VLOOKUP(C150,cost12w,10,FALSE)","v":35963.129999999997}]
[null,null,"G1 TE III"]
[null,null,"Weighted",null,0.88263785394932937,{"$f":"AVERAGE(F153:F153)","v":38979.99},{"$f":"AVERAGE(G153:G153)","v":38979.99}]
[null,null,"SOF+LED","G1 TE III_SOF+LED",0.86363636363636365,{"$f":"VLOOKUP(C153,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C153,cost12w,10,FALSE)","v":38979.99}]
[null,null,"G3 TN IE"]
[null,null,"Weighted",null,0.83333333333333337,{"$f":"F156","v":37435.079999999994},{"$f":"G156","v":37435.079999999994}]
[null,null,"SOF+PR","G3 TN IE_SOF+PR",0.83333333333333337,{"$f":"VLOOKUP(C156,cost12w,2,FALSE)","v":37435.079999999994},{"$f":"VLOOKUP(C156,cost12w,10,FALSE)","v":37435.079999999994}]
[null,null,"G3 TE IE"]
[null,null,"Weighted",null,0.83333333333333337,{"$f":"F159","v":37435.079999999994},{"$f":"G159","v":37435.079999999994}]
[null,null,"SOF+PR","G3 TE IE_SOF+PR",0.83333333333333337,{"$f":"VLOOKUP(C159,cost12w,2,FALSE)","v":37435.079999999994},{"$f":"VLOOKUP(C159,cost12w,10,FALSE)","v":37435.079999999994}]
[null,null,"G3 TN III"]
[null,null,"Weighted",null,0.78947368421052633,{"$f":"AVERAGE(F162:F163)","v":50203.604999999996},{"$f":"AVERAGE(G162:G163)","v":50203.604999999996}]
[null,null,"SOF+LED+R","G3 TN III_SOF+LED+R",1,{"$f":"VLOOKUP(C162,cost12w,2,FALSE)","v":39944.129999999997},{"$f":"VLOOKUP(C162,cost12w,10,FALSE)","v":39944.129999999997}]
[null,null,"SOF+DCV+R","G3 TN III_SOF+DCV+R",0.57894736842105265,{"$f":"VLOOKUP(C163,cost12w,2,FALSE)","v":60463.08},{"$f":"VLOOKUP(C163,cost12w,10,FALSE)","v":60463.08}]
[null,null,"G3 TE III"]
[null,null,"Weighted",null,0.7325174825174825,{"$f":"AVERAGE(F166:F167)","v":50203.604999999996},{"$f":"AVERAGE(G166:G167)","v":50203.604999999996}]
[null,null,"SOF+LED+R","G3 TE III_SOF+LED+R",0.77272727272727271,{"$f":"VLOOKUP(C166,cost12w,2,FALSE)","v":39944.129999999997},{"$f":"VLOOKUP(C166,cost12w,10,FALSE)","v":39944.129999999997}]
[null,null,"SOF+DCV+R","G3 TE III_SOF+DCV+R",0.69230769230769229,{"$f":"VLOOKUP(C167,cost12w,2,FALSE)","v":60463.08},{"$f":"VLOOKUP(C167,cost12w,10,FALSE)","v":60463.08}]
[null,null,"G4 TN IE"]
[null,null,"Weighted",null,0.80392156862745101,{"$f":"AVERAGE(F170:F171)","v":33141.134999999995},{"$f":"AVERAGE(G170:G171)","v":33141.135000000002}]
[null,null,"SMV+PR","G4 TN IE_SMV+PR",0.66666666666666663,{"$f":"VLOOKUP(C170,cost12w,2,FALSE)","v":27302.28},{"$f":"VLOOKUP(C170,cost12w,10,FALSE)","v":27302.280000000002}]
[null,null,"SOF+LED","G4 TN IE_SOF+LED",0.94117647058823528,{"$f":"VLOOKUP(C171,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C171,cost12w,10,FALSE)","v":38979.99}]
[null,null,"G4 TE IE"]
[null,null,"Weighted",null,0.62747035573122534,{"$f":"AVERAGE(F174:F175)","v":33141.134999999995},{"$f":"AVERAGE(G174:G175)","v":33141.135000000002}]
[null,null,"SMV+PR","G4 TE IE_SMV+PR",0.39130434782608697,{"$f":"VLOOKUP(C174,cost12w,2,FALSE)","v":27302.28},{"$f":"VLOOKUP(C174,cost12w,10,FALSE)","v":27302.280000000002}]
[null,null,"SOF+LED","G4 TE IE_SOF+LED",0.86363636363636365,{"$f":"VLOOKUP(C175,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C175,cost12w,10,FALSE)","v":38979.99}]
[null,null,"G4 TN III"]
[null,null,"Weighted",null,0.94117647058823528,{"$f":"F178","v":38979.99},{"$f":"G178","v":38979.99}]
[null,null,"SOF+LED","G4 TN III_SOF+LED",0.94117647058823528,{"$f":"VLOOKUP(C178,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C178,cost12w,10,FALSE)","v":38979.99}]
[null,null,"G4 TE III"]
[null,null,"Weighted",null,0.86363636363636365,{"$f":"F181","v":38979.99},{"$f":"G181","v":38979.99}]
[null,null,"SOF+LED","G4 TE III_SOF+LED",0.86363636363636365,{"$f":"VLOOKUP(C181,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C181,cost12w,10,FALSE)","v":38979.99}]
[]
[]
[null,null,"Costs in decompensated cirrhotic patients"]
[]
[null,null,"This section calculates the cost of treating patients at the decompensated cirrhotic stage."]
[null,null,"The treatment is a composite treatment strategy that is employed once."]
[null,null,"Its costs corresponds to the weighted average of the treatments used in the early access programme by NHS England."]
[]
[null,null,null,null,"Cost pre-discount","Cost post-discount"]
[null,null,null,"DC_SVRG1",{"$f":"SUMPRODUCT($F$196:$F$199,G196:G199)","v":44203.193234042548},{"$f":"SUMPRODUCT($F$196:$F$199,H196:H199)","v":44203.193234042548}]
[null,null,null,"DC_SVRG3",{"$f":"SUMPRODUCT(F201:F204,G201:G204)","v":53009.182857142856},{"$f":"SUMPRODUCT(F201:F204,H201:H204)","v":53009.182857142856}]
[]
[]
[null,null,"Regimen","Genotype","N ","Weights","Cost (12 weeks)","Cost new"]
[null,null,"SOF+LED+R",1,164,{"$f":"E196/$E$200","v":0.69787234042553192},{"$f":"VLOOKUP(C196,cost12w,2,FALSE)","v":39944.129999999997},{"$f":"VLOOKUP(C196,cost12w,10,FALSE)","v":39944.129999999997}]
[null,null,"SOF+LED",1,21,{"$f":"E197/$E$200","v":8.9361702127659579E-2},{"$f":"VLOOKUP(C197,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C197,cost12w,10,FALSE)","v":38979.99}]
[null,null,"SOF+DCV+R",1,45,{"$f":"E198/$E$200","v":0.19148936170212766},{"$f":"VLOOKUP(C198,cost12w,2,FALSE)","v":60463.08},{"$f":"VLOOKUP(C198,cost12w,10,FALSE)","v":60463.08}]
[null,null,"SOF+DCV",1,5,{"$f":"E199/$E$200","v":2.1276595744680851E-2},{"$f":"VLOOKUP(C199,cost12w,2,FALSE)","v":59498.94},{"$f":"VLOOKUP(C199,cost12w,10,FALSE)","v":59498.94}]
[null,null,null,"Total",{"$f":"SUM(E196:E199)","v":235}]
[null,null,"SOF+LED+R",3,61,{"$f":"E201/$E$205","v":0.32275132275132273},{"$f":"VLOOKUP(C201,cost12w,2,FALSE)","v":39944.129999999997},{"$f":"VLOOKUP(C201,cost12w,10,FALSE)","v":39944.129999999997}]
[null,null,"SOF+LED",3,7,{"$f":"E202/$E$205","v":3.7037037037037035E-2},{"$f":"VLOOKUP(C202,cost12w,2,FALSE)","v":38979.99},{"$f":"VLOOKUP(C202,cost12w,10,FALSE)","v":38979.99}]
[null,null,"SOF+DCV+R",3,114,{"$f":"E203/$E$205","v":0.60317460317460314},{"$f":"VLOOKUP(C203,cost12w,2,FALSE)","v":60463.08},{"$f":"VLOOKUP(C203,cost12w,10,FALSE)","v":60463.08}]
[null,null,"SOF+DCV",3,7,{"$f":"E204/$E$205","v":3.7037037037037035E-2},{"$f":"VLOOKUP(C204,cost12w,2,FALSE)","v":59498.94},{"$f":"VLOOKUP(C204,cost12w,10,FALSE)","v":59498.94}]
[null,null,null,"Total",{"$f":"SUM(E201:E204)","v":189}]
[]
[null,null,"Cost-effectiveness threshold"]
[]
[]
[null,null,{"$f":"IF(D210=\"\",'Price inputs'!J21,D210)","v":20000},20000]

{"sheet":"Calculations 2","index":4,"n_rows":649,"n_cols":49,"rows_kept":649,"cut":false,"hidden":true,"merged":[[14,12,14,19],[14,20,14,28],[14,47,14,48],[14,44,14,46],[13,12,13,19],[14,32,14,34],[14,35,14,37],[14,38,14,40],[14,41,14,43]]}
[]
[]
[]
[null,null,"Background calculations - part 2"]
[]
[null,null,"This sheet calculates the incremental costs, incremental QALYs and ICERs of all strategies for each subgroup. "]
[]
[null,null,"Parameters required for the macro to calculate the cost-effective strategies:"]
[]
[null,null,null,"N.comparators",{"$f":"COUNT(D17:D649)","v":633},null,"N.TN",{"$f":"COUNTIF(F17:F649,0)","v":518}]
[]
[null,null,null,"N.subgroups",{"$f":"SUM(1/COUNTIF(C17:C649,C17:C649))","v":13.999999999999979},null,"N.results",{"$f":"COUNT(M17:AE17)","v":19}]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,"Costs",null,null,null,null,null,null,null,"Proportion of patients by outcome",null,null,null,null,null,null,null,null,null,null,null,"F3 treatment 1st line",null,null,"F3 treatment 2nd line",null,null,"F3 treatment 3rd line",null,null,"Cirrhosis treatment",null,null,"Decompensated cirrhosis treatment",null,null,"Results"]
[null,null,"Subgroup.ID","Genotype","Interferon ","TE","Strategies F3 (1)","Strategies F3 (2)","Strategies F3 (4)","Strategies F4 ","Strategy DC","Name","Treatment F3 - 1","Treatment F3 - 2","Treatment F3 - 3","Treatment F4","Treatment DC","Monitoring","Health state","Total costs","SVR F3 1st line","SVR F3 2nd line","SVR F3 3rd line","SVR F3 total","SVR cirrhosis","SVR decompensated cirrhosis","No SVR","Progressing to cirrhosis","Progressing to decompensated cirrhosis","Life years ","QALYs","ICER","Price old ","Price new","Treatment cost new","Price old ","Price new","Treatment cost new","Price old ","Price new","Treatment cost new","Price old ","Price new","Treatment cost new","Price old ","Price new","Treatment cost new","Total costs new","ICER new"]
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[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+DCV12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_SOF+DCV12",39352.479811209465,2518.9929868513254,0,171.13785475720303,4.0310767930407421,736.53031202254806,1372.5447661666367,44155.71680780017,0.92413117791290877,3.7950518762196898E-2,0,0.96208169667510879,3.6545015743123313E-2,8.4101424638963573E-5,1.2891861571293997E-3,3.6803982707861303E-2,1.2062932137749525E-2,18.752769560081124,11.986085143558473,null,39453.265115207367,39453.265115207367,39352.479811209465,59498.94,59498.94,2518.9929868513254,0,0,0,43674.259999999995,43674.259999999995,171.13785475720303,53009.182857142856,53009.182857142856,4.0310767930407421,44155.71680780017,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+PR12","G3_TE IE_SOF+LED+R12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+PR12G3_TE IE_SOF+LED+R12",36568.729715363246,1852.9656015660757,0,256.64924649761781,6.1027663047284122,734.65002374205596,1437.1247358152302,40856.222089288873,0.9200358947737568,3.925077994563194E-2,0,0.95928667471939066,3.8738169534629191E-2,1.2975868511312143E-4,1.8453970608681722E-3,3.9139726118333891E-2,1.2744446101234493E-2,18.750907846507015,11.951010023041151,null,36655.182499999995,36655.182499999995,36568.729715363246,39944.129999999997,39944.129999999997,1852.9656015660757,0,0,0,43674.259999999995,43674.259999999995,256.64924649761781,53009.182857142856,53009.182857142856,6.1027663047284122,40856.222089288873,"Extended dominance"]
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[null,null,"310",3,1,0,"G3_TN IE_SOF+PR12","G3_TE IE_SOF+DCV12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+PR12G3_TE IE_SOF+DCV12",36568.729715363246,2760.0923877837536,0,186.65478252111899,4.4420267009240924,733.5303797721981,1384.6261238456875,41638.075415987063,0.9200358947737568,4.1585918364306411E-2,0,0.9616218131380655,3.6916633101845758E-2,9.2762668605558265E-5,1.3687910914846389E-3,3.7200374314560219E-2,1.2187527288256178E-2,18.752398517066474,11.955242272658912,null,36655.182499999995,36655.182499999995,36568.729715363246,59498.94,59498.94,2760.0923877837536,0,0,0,43674.259999999995,43674.259999999995,186.65478252111899,53009.182857142856,53009.182857142856,4.4420267009240924,41638.075415987063,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+RBV24","G3_TE IE_SOF+LED+R12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+RBV24G3_TE IE_SOF+LED+R12",70742.955950142117,2749.2459976096416,0,480.12768449603107,11.480269291785859,919.46582090735035,2448.9891514042679,77352.264873851338,0.86631038998379661,5.8858704502915735E-2,0,0.92516909448670914,7.1454793945742709E-2,2.3987048439832973E-4,3.1362410831475823E-3,7.21836548464075E-2,2.3486831895598477E-2,18.703724460637833,11.858619045048513,null,70935.571199999991,{"$f":"VLOOKUP(G209,F3_treat_duration,17,FALSE)","v":70935.571199999991},70742.955950142117,39944.129999999997,{"$f":"IF(H209=\"\",0,VLOOKUP(H209,F3_treat_duration,17,FALSE))","v":39944.129999999997},2749.2459976096416,0,{"$f":"IF(I209=\"\",0,VLOOKUP(I209,F3_treat_duration,17,FALSE))","v":0},0,{"$f":"VLOOKUP(J209,F4_treatments,2,FALSE)","v":43674.259999999995},{"$f":"VLOOKUP(J209,F4_treatments,3,FALSE)","v":43674.259999999995},480.12768449603101,{"$f":"VLOOKUP(K209,DC_treatments,2,FALSE)","v":53009.182857142856},{"$f":"VLOOKUP(K209,DC_treatments,3,FALSE)","v":53009.182857142856},11.480269291785859,77352.264873851338,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+RBV24","G3_TE IE_SOF+PR12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+RBV24G3_TE IE_SOF+PR12",70742.955950142117,2434.3133117529119,0,639.8022774451963,15.176500611357383,919.29796391746163,2567.8818904854211,77319.427894354434,0.86631038998379661,5.3434578860012058E-2,0,0.91974496884380752,7.5663861161604923E-2,3.2303794082803904E-4,4.2681320537594058E-3,7.6663807939052808E-2,2.4699068625130442E-2,18.700472509980042,11.846399907889985,null,{"$f":"VLOOKUP(G210,F3_treat_duration,13,FALSE)","v":70935.571199999991},70935.571199999991,{"$f":"IF(AG210=0,0,AH210*M210/AG210)","v":70742.955950142117},{"$f":"IF(H210=\"\",0,VLOOKUP(H210,F3_treat_duration,13,FALSE))","v":35355.353333333333},35355.353333333333,{"$f":"IF(AJ210=0,0,AK210*N210/AJ210)","v":2434.3133117529119},{"$f":"IF(I210=\"\",0,VLOOKUP(I210,F3_treat_duration,13,FALSE))","v":0},0,{"$f":"IF(AM210=0,0,AN210*O210/AM210)","v":0},43674.259999999995,43674.259999999995,{"$f":"AQ210*P210/AP210","v":639.8022774451963},53009.182857142856,53009.182857142856,{"$f":"AT210*Q210/AS210","v":15.176500611357383},{"$f":"T210-SUM(M210:Q210)+SUM(AI210,AL210,AO210,AR210,AU210)","v":77319.427894354434},"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+RBV24","G3_TE IE_PR48",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+RBV24G3_TE IE_PR48",70742.955950142117,418.89080973971227,0,1024.8623521839404,24.064832808963562,929.20760022840841,2955.3838470456499,76095.365392148728,0.86631038998379661,3.7028964465613795E-2,0,0.9033393544494086,8.913254755857021E-2,5.232273852832321E-4,7.0048706067373347E-3,9.0776726795779777E-2,2.8747458760298321E-2,18.688329040859056,11.808696935222557,null,70935.571199999991,70935.571199999991,70742.955950142117,6085.3591148002761,6085.3591148002752,418.89080973971221,0,0,0,43674.259999999995,43674.259999999995,1024.8623521839404,53009.182857142856,53009.182857142856,24.064832808963562,76095.365392148728,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+RBV24","G3_TE IE_SOF+DCV12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+RBV24G3_TE IE_SOF+DCV12",70742.955950142117,4095.1504678413721,0,379.3819765624138,9.0728884414549675,917.85493439384629,2372.9460790324852,78517.362296413325,0.86631038998379661,6.2277458563206073E-2,0,0.92858784854700172,6.8799478402987502E-2,1.8586415240403573E-4,2.4268088976065424E-3,6.9356039262565727E-2,2.2683212984403619E-2,18.70586658595499,11.864744742329432,null,70935.571199999991,70935.571199999991,70742.955950142117,59498.94,59498.94,4095.1504678413721,0,0,0,43674.259999999995,43674.259999999995,379.3819765624138,53009.182857142856,53009.182857142856,9.0728884414549675,78517.362296413325,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_PR24","G3_TE IE_SOF+LED+R12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_PR24G3_TE IE_SOF+LED+R12",4099.3935893960261,10696.030310527109,0,1868.5437872016678,44.536657181152194,953.99279833597222,3239.814866494728,20902.312009136695,0.66364328535652339,0.22897478767995186,0,0.89261807303647356,9.7290623067182461E-2,9.3077759093894864E-4,9.1605263054042665E-3,0.1001186330924988,3.1765896049044784E-2,18.675988332353793,11.768103785258193,null,4110.4459259259265,4110.4459259259256,4099.3935893960252,39944.129999999997,39944.129999999997,10696.030310527109,0,0,0,43674.259999999995,43674.259999999995,1868.5437872016678,53009.182857142856,53009.182857142856,44.536657181152201,20902.312009136695,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_PR24","G3_TE IE_SOF+PR12",null,"G3 TE IE_F4SVR","DC_SVRG3",{"$f":"G214&H214&I214","v":"G3_TN IE_PR24G3_TE IE_SOF+PR12"},4099.3935893960261,9469.6730802841575,0,2485.7781074538384,59.003156324556912,953.24540716935826,3701.9273084269298,20769.020649054841,0.66364328535652339,0.2079105298463122,0,0.87155381520283692,0.11355063186161408,1.2567540383219306E-3,1.3638798897229113E-2,0.11743729005521442,3.6474536303102718E-2,18.663241264559304,11.720984045033553,null,4110.4459259259265,4110.4459259259256,4099.3935893960252,35355.353333333333,35355.353333333333,9469.6730802841575,0,0,0,43674.259999999995,43674.259999999995,2485.7781074538384,53009.182857142856,53009.182857142856,59.003156324556912,20769.020649054837,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_PR24","G3_TE IE_SOF+RBV24",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_PR24G3_TE IE_SOF+RBV24",4099.3935893960261,18995.629068772887,0,2056.7481066494674,48.864057225661483,997.48319860381594,3573.6505022481288,29771.76852289592,0.66364328535652339,0.21613149682925475,0,0.87977478218577621,0.10860491251951493,1.028080892989458E-3,1.059222440171796E-2,0.11174899380368632,3.5235220067297762E-2,18.663632843278606,11.731014839440746,null,4110.4459259259265,4110.4459259259256,4099.3935893960252,70935.571199999991,70935.571199999991,18995.629068772887,0,0,0,43674.259999999995,43674.259999999995,2056.7481066494674,53009.182857142856,53009.182857142856,48.864057225661483,29771.76852289592,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_PR24","G3_TE IE_SOF+DCV12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_PR24G3_TE IE_SOF+DCV12",4099.3935893960261,15932.315103226287,0,1472.6545702114317,35.214283364460343,947.6524435596923,2940.5362642868954,25427.7662540448,0.66364328535652339,0.24240893923206605,0,0.90605222458859047,8.6847876154925313E-2,7.2145984299571797E-4,6.378439413490161E-3,8.9007027922953702E-2,2.8596202299311171E-2,18.684442117952589,11.792188471220323,null,4110.4459259259265,4110.4459259259256,4099.3935893960252,59498.94,59498.94,15932.315103226287,0,0,0,43674.259999999995,43674.259999999995,1472.6545702114317,53009.182857142856,53009.182857142856,35.214283364460343,25427.7662540448,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+DCV12","G3_TE IE_SOF+LED+R12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+DCV12G3_TE IE_SOF+LED+R12",59341.698264514387,1478.8051648234189,0,204.32713102745805,4.8862269244681773,741.8207639676383,1399.0226583678166,63170.560209628442,0.92950266700196316,3.1370368320520786E-2,0,0.96087303532248636,3.7449794192975609E-2,1.0365796089790817E-4,1.5735125236403661E-3,3.7769240925048624E-2,1.2345257237863163E-2,18.752171572205299,11.979987684408663,null,59498.94,59498.94,59341.698264514387,39944.129999999997,39944.129999999997,1478.8051648234189,0,0,0,43674.259999999995,43674.259999999995,204.32713102745805,53009.182857142856,53009.182857142856,4.8862269244681773,63170.560209628442,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+DCV12","G3_TE IE_SOF+PR12",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+DCV12G3_TE IE_SOF+PR12",59341.698264514387,1309.7731398406725,0,291.61777700174935,6.9828415720518917,741.75832819704897,1463.5236270603236,63155.353978189232,0.92950266700196316,2.8483479458158857E-2,0,0.95798614646012425,3.9701655188845379E-2,1.5043971442783833E-4,2.1617586366027117E-3,4.0170864309975948E-2,1.3004207032303089E-2,18.750382551055264,11.973321751597339,null,59498.94,59498.94,59341.698264514387,35355.353333333333,35355.353333333333,1309.7731398406725,0,0,0,43674.259999999995,43674.259999999995,291.61777700174935,53009.182857142856,53009.182857142856,6.9828415720518917,63155.353978189232,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+DCV12","G3_TE IE_SOF+RBV24",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+DCV12G3_TE IE_SOF+RBV24",59341.698264514387,2626.1556791873286,0,232.07814829711182,5.5524021950540456,747.87680954472944,1447.0169022530888,64400.378205995024,0.92950266700196316,2.9535616486259929E-2,0,0.95903828348822628,3.9075953664894518E-2,1.1852860631715637E-4,1.7672342405630214E-3,3.9443082261437043E-2,1.2844867909583406E-2,18.750361175141812,11.974596423750747,null,59498.94,59498.94,59341.698264514387,70935.571199999991,70935.571199999991,2626.1556791873286,0,0,0,43674.259999999995,43674.259999999995,232.07814829711185,53009.182857142856,53009.182857142856,5.5524021950540456,64400.378205995024,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+DCV12","G3_TE IE_PR48",null,"G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+DCV12G3_TE IE_PR48",59341.698264514387,225.34524037146394,0,500.12373141576899,11.867893731314657,747.05064942870194,1674.7781771487014,62500.86395661367,0.92950266700196316,1.9658435924658536E-2,0,0.94916110292662126,4.6969134920072764E-2,2.5961473103596264E-4,3.6101474222675787E-3,4.7787490049298754E-2,1.5206498114471678E-2,18.743594213992317,11.952668448041422,null,59498.94,59498.94,59341.698264514387,6085.3591148002761,6085.3591148002752,225.34524037146392,0,0,0,43674.259999999995,43674.259999999995,500.12373141576893,53009.182857142856,53009.182857142856,11.867893731314657,62500.86395661367,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+PR12","G3_TE IE_SOF+RBV24","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_SOF+PR12G3_TE IE_SOF+RBV24",39352.479811209465,1495.8145102631761,624.19352251706596,120.4654755074298,2.9070222447752809,741.58347466639248,1341.4076928471904,43678.851509255561,0.92413117791290877,3.2455482799265564E-2,7.0825656938755498E-3,0.96366922640605457,3.5362776276553147E-2,5.8223933474938252E-5,9.097733839196682E-4,3.5535300056414428E-2,1.174100325365127E-2,18.753484392822571,11.987376990693242,null,39453.265115207367,39453.265115207367,39352.479811209465,35355.353333333333,35355.353333333333,1495.8145102631761,70935.571199999991,70935.571199999991,624.19352251706596,43674.259999999995,43674.259999999995,120.4654755074298,53009.182857142856,53009.182857142856,2.9070222447752809,43678.851509255561,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+PR12","G3_TE IE_SOF+DCV12","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_SOF+PR12G3_TE IE_SOF+DCV12",39352.479811209465,1495.8145102631761,523.50662635857157,101.06506947463312,2.4473984376746234,739.98299310094285,1320.4314138154134,43535.727822659966,0.92413117791290877,3.2455482799265564E-2,7.9541323660433996E-3,0.96454079307822005,3.4640636485668043E-2,4.7898940168710822E-5,7.706714959432138E-4,3.4779923372235143E-2,1.1520736403349996E-2,18.754165390273442,11.989411988077951,null,39453.265115207367,39453.265115207367,39352.479811209465,35355.353333333333,35355.353333333333,1495.8145102631761,59498.94,59498.94,523.50662635857157,43674.259999999995,43674.259999999995,101.06506947463312,53009.182857142856,53009.182857142856,2.4473984376746234,43535.727822659966,136072.1657708092]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+RBV24","G3_TE IE_SOF+PR12","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_SOF+RBV24G3_TE IE_SOF+PR12",39352.479811209465,3003.2661392874779,218.50847988681028,123.62454076976155,2.9755951331153701,746.11843785041617,1369.3211504640831,44816.294154601099,0.92413117791290877,3.3797619057111358E-2,4.818313904036039E-3,0.96274711087405973,3.6264450197450962E-2,5.9576150882771704E-5,9.288627776075179E-4,3.6440868608782637E-2,1.2036465809505247E-2,18.75215684718837,11.984934873596455,null,39453.265115207367,39453.265115207367,39352.479811209465,70935.571199999991,70935.571199999991,3003.2661392874779,35355.353333333333,35355.353333333333,218.50847988681028,43674.259999999995,43674.259999999995,123.62454076976155,53009.182857142856,53009.182857142856,2.9755951331153705,44816.294154601099,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+RBV24","G3_TE IE_PR48","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_SOF+RBV24G3_TE IE_PR48",39352.479811209465,3003.2661392874779,37.632918603217909,157.03116238706596,3.7332062050625141,746.97768166509866,1403.3292241309427,44704.450143488255,0.92413117791290877,3.3797619057111358E-2,3.3579818944801817E-3,0.96128677886450375,3.7456404707765387E-2,7.6815551939709339E-5,1.1800008757921856E-3,3.7689116413456833E-2,1.2389815235617156E-2,18.751109463115711,11.981660406209768,null,39453.265115207367,39453.265115207367,39352.479811209465,70935.571199999991,70935.571199999991,3003.2661392874779,6085.3591148002761,6085.3591148002752,37.632918603217902,43674.259999999995,43674.259999999995,157.03116238706596,53009.182857142856,53009.182857142856,3.7332062050625141,44704.450143488255,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+RBV24","G3_TE IE_SOF+DCV12","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_SOF+RBV24G3_TE IE_SOF+DCV12",39352.479811209465,3003.2661392874779,367.97102614153641,99.540182965375379,2.4095258255409666,745.98329720610536,1351.3603239757506,44923.010306611213,0.92413117791290877,3.3797619057111358E-2,5.6413737728770036E-3,0.96357017074289719,3.562621912321827E-2,4.6784267305680775E-5,7.5682586657638891E-4,3.5761143508966919E-2,1.1848653880059167E-2,18.752630384947221,11.986620374065575,null,39453.265115207367,39453.265115207367,39352.479811209465,70935.571199999991,70935.571199999991,3003.2661392874779,59498.94,59498.94,367.97102614153647,43674.259999999995,43674.259999999995,99.540182965375394,53009.182857142856,53009.182857142856,2.4095258255409666,44923.010306611213,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_PR48","G3_TE IE_SOF+PR12","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_PR48G3_TE IE_SOF+PR12",39352.479811209465,257.60140939772089,519.83229357064067,242.61737870263778,5.786962012506895,748.07749979430639,1486.9267370851117,42613.322091772323,0.92413117791290877,2.2496987748670965E-2,1.169374998995225E-2,0.95832191565153468,4.0098033312910231E-2,1.1888041618012466E-4,1.4611706193751763E-3,4.0456162301789576E-2,1.3258078824483545E-2,18.747673497355812,11.971297508688336,null,39453.265115207367,39453.265115207367,39352.479811209465,6085.3591148002761,6085.3591148002752,257.60140939772089,35355.353333333333,35355.353333333333,519.83229357064067,43674.259999999995,43674.259999999995,242.61737870263778,53009.182857142856,53009.182857142856,5.786962012506895,42613.322091772323,"Extended dominance"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_PR48","G3_TE IE_SOF+RBV24","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_PR48G3_TE IE_SOF+RBV24",39352.479811209465,257.60140939772089,1043.7332345517809,217.91489007425611,5.1984772801494481,750.44374755903277,1478.5171018195201,43105.888671891829,0.92413117791290877,2.2496987748670965E-2,1.2221109221981873E-2,0.95884927488356497,3.9761626564114527E-2,1.0541211758733109E-4,1.2836864347341896E-3,4.0075518273216412E-2,1.3170137759036523E-2,18.747692598175249,11.971987435010202,null,39453.265115207367,39453.265115207367,39352.479811209465,6085.3591148002761,6085.3591148002752,257.60140939772089,70935.571199999991,70935.571199999991,1043.7332345517809,43674.259999999995,43674.259999999995,217.91489007425611,53009.182857142856,53009.182857142856,5.1984772801494481,43105.888671891829,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_PR48","G3_TE IE_SOF+DCV12","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_PR48G3_TE IE_SOF+DCV12",39352.479811209465,257.60140939772089,875.40391112975828,186.85161897485506,4.4823152768271184,747.78067526154007,1444.9026137860387,42869.5023550361,0.92413117791290877,2.2496987748670965E-2,1.3669693196019428E-2,0.96029785885760044,3.8582625968379247E-2,8.8955226284587386E-5,1.0305599477345294E-3,3.8842598306523271E-2,1.2819237739754024E-2,18.748693615640402,11.975156869868156,null,39453.265115207367,39453.265115207367,39352.479811209465,6085.3591148002761,6085.3591148002752,257.60140939772089,59498.94,59498.94,875.40391112975828,43674.259999999995,43674.259999999995,186.85161897485506,53009.182857142856,53009.182857142856,4.4823152768271184,42869.5023550361,"Extended dominance"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+DCV12","G3_TE IE_SOF+PR12","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_SOF+DCV12G3_TE IE_SOF+PR12",39352.479811209465,2518.9929868513254,120.20153288643689,92.897723336537368,2.2427818974998384,737.57400696722459,1314.9957564901872,44139.384599638805,0.92413117791290877,3.7950518762196898E-2,2.6305008820680428E-3,0.96471219755717841,3.4482995254815643E-2,4.4017454985025616E-5,7.6078973302307095E-4,3.4611433802870087E-2,1.1463342910736824E-2,18.754434146896006,11.990984237808163,null,39453.265115207367,39453.265115207367,39352.479811209465,59498.94,59498.94,2518.9929868513254,35355.353333333333,35355.353333333333,120.20153288643691,43674.259999999995,43674.259999999995,92.897723336537368,53009.182857142856,53009.182857142856,2.2427818974998384,44139.384599638805,383944.60396458168]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+DCV12","G3_TE IE_SOF+RBV24","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_SOF+DCV12G3_TE IE_SOF+RBV24",39352.479811209465,2518.9929868513254,241.51523537291482,87.020434557306061,2.106558320454289,738.11060415461702,1313.168508292795,44253.394138758769,0.92413117791290877,3.7950518762196898E-2,2.7418252385551364E-3,0.96482352191366483,3.441160283527725E-2,4.0975823155956449E-5,7.2389942790347585E-4,3.4530167590761662E-2,1.1444674543745882E-2,18.754443829041975,11.991139029606948,null,39453.265115207367,39453.265115207367,39352.479811209465,59498.94,59498.94,2518.9929868513254,70935.571199999991,70935.571199999991,241.51523537291482,43674.259999999995,43674.259999999995,87.020434557306061,53009.182857142856,53009.182857142856,2.106558320454289,44253.394138758769,736534.49921062728]
[null,null,"310",3,1,0,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+DCV12","G3_TE IE_PR48","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+LED+R12G3_TE IE_SOF+DCV12G3_TE IE_PR48",39352.479811209465,2518.9929868513254,20.720770911721953,111.63682303256256,2.6712346210405551,738.04697448014792,1333.8513593721127,44078.399960478273,0.92413117791290877,3.7950518762196898E-2,1.8252754631248936E-3,0.96390697213823662,3.514505719741115E-2,5.3693013445469174E-5,8.9427765091028885E-4,3.5305069452544961E-2,1.1658735538074554E-2,18.753827257940806,11.989141287424866,null,39453.265115207367,39453.265115207367,39352.479811209465,59498.94,59498.94,2518.9929868513254,6085.3591148002761,6085.3591148002752,20.720770911721949,43674.259999999995,43674.259999999995,111.63682303256257,53009.182857142856,53009.182857142856,2.6712346210405546,44078.399960478273,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+PR12","G3_TE IE_SOF+LED+R12","G3_TE IE_SOF+RBV24","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+PR12G3_TE IE_SOF+LED+R12G3_TE IE_SOF+RBV24",36568.729715363246,1852.9656015660757,428.47298796808946,108.1628857902697,2.6371892732101179,737.51239809539504,1330.6849928804857,41029.165770936888,0.9200358947737568,3.925077994563194E-2,4.8722755536718112E-3,0.96415895027306131,3.496718007025397E-2,5.2083037035363772E-5,8.2178661964927083E-4,3.511840702632734E-2,1.1628150445688617E-2,18.75376641155664,11.959872321207001,null,36655.182499999995,36655.182499999995,36568.729715363246,39944.129999999997,39944.129999999997,1852.9656015660757,70935.571199999991,70935.571199999991,428.47298796808946,43674.259999999995,43674.259999999995,108.1628857902697,53009.182857142856,53009.182857142856,2.6371892732101174,41029.165770936888,"Dominated"]
[null,null,"310",3,1,0,"G3_TN IE_SOF+PR12","G3_TE IE_SOF+LED+R12","G3_TE IE_SOF+DCV12","G3 TE IE_F4SVR","DC_SVRG3","G3_TN IE_SOF+PR12G3_TE IE_SOF+LED+R12G3_TE IE_SOF+DCV12",36568.729715363246,1852.9656015660757,359.38836515586593,95.100665641505287,2.3296487978819322,736.37380346810141,1316.4672385608358,40931.355038553411,0.9200358947737568,3.925077994563194E-2,5.4602522181225839E-3,0.96474692693751263,3.4480288287799511E-2,4.5188976249692755E-5,7.2759579843863654E-4,3.4609383280460565E-2,1.1477933197537489E-2,18.754243371171128,11.961230673323747,null,36655.182499999995,36655.182499999995,36568.729715363246,39944.129999999997,39944.129999999997,1852.9656015660757,59498.94,59498.94,359.38836515586593,43674.259999999995,43674.259999999995,95.100665641505287,53009.182857142856,53009.182857142856,2.3296487978819322,40931.355038553411,"Extended dominance"]
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[null,null,"410",4,1,0,"G4_TN IE_SOF+LED12","G4_TE IE_SMV+PR12+48","G4_TE IE_DCV+PR24+48","G4 TE IE_F4SVR","DC_SVRG1","G4_TN IE_SOF+LED12G4_TE IE_SMV+PR12+48G4_TE IE_DCV+PR24+48",38453.280442068593,870.19133375991851,370.51508968484166,153.47838521109301,8.2057318205520229,730.58326939734866,1229.7144917038361,41815.96874364619,0.94975344818240803,1.3906267522920266E-2,4.4236302516196379E-3,0.96808334595694601,2.989945681555636E-2,2.7577805691387776E-4,1.7414191705820508E-3,3.0530786015883035E-2,1.0286086606714385E-2,18.768686360634934,12.017967106596585,null,38556.95134883721,38556.95134883721,38453.280442068593,35929.977777777778,35929.977777777778,870.19133375991851,46431.92646000001,46431.926460000002,370.51508968484154,45487.190232213426,45487.190232213441,153.47838521109307,44203.193234042548,44203.193234042548,8.2057318205520229,41815.96874364619,"Dominated"]
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[null,null,"410",4,1,0,"G4_TN IE_SOF+LED12","G4_TE IE_PR48","G4_TE IE_SOF+DCV12","G4 TE IE_F4SVR","DC_SVRG1","G4_TN IE_SOF+LED12G4_TE IE_PR48G4_TE IE_SOF+DCV12",38453.280442068593,154.42514858679868,953.9976637871722,120.91637699515472,6.6353597639763242,736.27429544835184,1171.220559516011,41596.749846166094,0.94975344818240803,5.5037613609796076E-3,1.5599457493625716E-2,0.97085666703701279,2.7935228597205129E-2,2.0666133603040608E-4,1.0014430297512883E-3,2.8371766483856128E-2,9.6872829077723661E-3,18.769645444163629,12.022379806955424,null,38556.95134883721,38556.95134883721,38453.280442068593,6379.3531788079472,6379.3531788079463,154.42514858679866,59498.94,59498.94,953.9976637871722,45487.190232213426,45487.190232213441,120.91637699515476,44203.193234042548,44203.193234042548,6.6353597639763242,41596.749846166094,"Dominated"]
[null,null,"410",4,1,0,"G4_TN IE_SOF+LED12","G4_TE IE_PR48","G4_TE IE_DCV+PR24+48","G4 TE IE_F4SVR","DC_SVRG1","G4_TN IE_SOF+LED12G4_TE IE_PR48G4_TE IE_DCV+PR24+48",38453.280442068593,154.42514858679868,744.51199428128643,293.32790166596317,15.599473988294676,737.00182082870924,1335.08815684876,41733.234938268426,0.94975344818240803,5.5037613609796076E-3,8.3811022613504479E-3,0.96363831180473791,3.2799081033167393E-2,5.3289931441533067E-4,3.0297078476794999E-3,3.4037307271352325E-2,1.1353623446505305E-2,18.766158259388121,12.009358657735431,null,38556.95134883721,38556.95134883721,38453.280442068593,6379.3531788079472,6379.3531788079463,154.42514858679866,46431.92646000001,46431.926460000002,744.51199428128632,45487.190232213426,45487.190232213441,293.32790166596322,44203.193234042548,44203.193234042548,15.599473988294676,41733.234938268426,"Dominated"]
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[null,null,{"$f":"D494&E494&F494","v":"400"},4,0,0,"NT",null,null,"G4 TN III_F4SVR","DC_SVRG1",{"$f":"G494&H494&I494","v":"NT"},0,0,0,25198.387986630547,133.63473097333815,429.15849516515988,21700.203365403428,47461.384578172598,0,0,0,0,0.78421150488261326,4.6825623208551683E-3,0.21110593279653136,0.79535501655927909,0.21706105827411554,18.359220659755515,10.458206189835712,null,0,0,0,0,0,0,0,0,0,41272.930588235293,41272.930588235293,25198.387986630547,44203.193234042548,44203.193234042548,133.63473097333815,47461.384578172598,"Dominated"]
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[null,null,"400",4,0,0,"G4_TN III_SOF+LED12","G4_TE III_SOF+RBV24",null,"G4 TE III_F4SVR","DC_SVRG1","G4_TN III_SOF+LED12G4_TE III_SOF+RBV24",38456.40139614886,1670.4775138525515,0,319.83830909332789,3.8546225867189157,729.92069975846255,1317.1445964049378,42497.637137844722,0.94971650099854044,1.3007342777029888E-2,0,0.96272384377556774,3.4166851527620279E-2,1.3379726332923204E-4,2.9755074334822575E-3,3.4482824883782563E-2,1.1169554810261353E-2,18.768210015812173,12.013886125832192,null,38556.95134883721,38556.95134883721,38456.40139614886,68898.569999999978,68898.569999999978,1670.4775138525515,0,0,0,44295.443181818177,44295.443181818177,319.83830909332789,44203.193234042548,44203.193234042548,3.8546225867189157,42497.637137844722,"Dominated"]
[null,null,"400",4,0,0,"G4_TN III_SOF+LED12","G4_TE III_2D+R12",null,"G4 TE III_F4SVR","DC_SVRG1","G4_TN III_SOF+LED12G4_TE III_2D+R12",38456.40139614886,804.09825854565747,0,41.685901016236443,0.51947867422823246,722.44594636188572,1092.5707471271655,41117.721727874021,0.94971650099854044,2.3421508850760324E-2,0,0.97313800984929821,2.6180468988153332E-2,1.6220401896271214E-5,6.6530076065184963E-4,2.6215332709827722E-2,8.8909049415832365E-3,18.772833933846492,12.031327448185944,null,38556.95134883721,38556.95134883721,38456.40139614886,33164.129999999997,33164.129999999997,804.09825854565747,0,0,0,44295.443181818177,44295.443181818177,41.685901016236443,44203.193234042548,44203.193234042548,0.51947867422823246,41117.721727874021,"Extended dominance"]
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[null,null,"400",4,0,0,"G4_TN III_2D+R12","G4_TE III_SOF+LED12",null,"G4 TE III_F4SVR","DC_SVRG1","G4_TN III_2D+R12G4_TE III_SOF+LED12",32548.074755957565,850.96648318421205,0,59.775509572474938,0.73947658586819109,717.28845742369288,1106.7725128227387,35283.617195546583,0.95215737014187274,2.028484047101586E-2,0,0.97244221061289093,2.669749102126006E-2,2.4161602798331736E-5,8.3613676305109564E-4,2.6751714254817271E-2,9.0361805444996255E-3,18.772604251318683,12.017184596076065,null,32637.715238095232,32637.715238095232,32548.074755957565,38979.99,38979.99,850.96648318421205,0,0,0,44295.443181818177,44295.443181818177,59.775509572474945,44203.193234042548,44203.193234042548,0.73947658586819109,35283.617195546583]
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{"sheet":"Calculations 3","index":5,"n_rows":406,"n_cols":35,"rows_kept":406,"cut":false,"hidden":true,"merged":[[8,2,8,17],[8,34,9,34],[8,21,8,23],[8,26,8,28],[8,29,8,31],[8,32,9,32],[8,33,9,33],[9,15,10,15],[9,16,10,16],[9,17,10,17],[9,4,9,8],[8,19,9,19],[8,20,9,20]]}
[]
[]
[null,null,"Background calculations - part 3"]
[]
[null,null,"This sheet extracts the strategies in the cost-effectiveness frontier from the 'results' sheet. It also creates a table with the cost-effective strategy for each subgroup for a given threshold."]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,2,3,4,5,6,7,8,9,10,11,12,13,14]
[]
[null,null,"Strategies in the cost-effectiveness frontier per subgroup",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Subgroup","Net benefit","Cost-effective strategies",null,null,null,null,"SVR rate",null,null,"Treatment cost",null,null,"Total costs","Total QALYs","ICER"]
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[null,null,223913.40506293971,210,"G2_TN IE_PR24","G2_TE IE_SOF+RBV12",null,"G3 TE IE_F4SVR","DC_SVRG3",0.77349890084413542,0.16949954051276978,0,4101.5,6731.12,0,14474.83,11.919411753145216,0,null,410,{"$f":"MAX(IF($D$12:$D$406=T22,$C$12:$C$406))","v":206169.82943493593},"G4_TN IE_PR48","G4_TE IE_2D+R12","G4_TE IE_SOF+LED12","G4 TE IE_F4SVR","DC_SVRG1",0.45873492489105433,0.42810845896261779,7.9765315843272205E-3,6431.08,14319.79,322.73,28099.49,11.713465971729942,"Lowest cost"]
[null,null,202348.8439960377,210,"G2_TN IE_SOF+RBV12","G2_TE IE_PR48",null,"G3 TE IE_F4SVR","DC_SVRG3",0.93823813453079674,2.5655490855901703E-2,0,35052.04,267.2,0,37778.67,12.006375699782117,267971.19612452749,null,411,{"$f":"MAX(IF($D$12:$D$406=T23,$C$12:$C$406))","v":206169.82943479973},"G4_TN IE_PR48","G4_TE IE_2D+R12","G4_TE IE_SOF+LED12","G4 TE IE_F4SVR","DC_SVRG1",0.45873492489105433,0.42810845896261779,7.9765315843272205E-3,6431.08,14319.79,322.73,28099.49,11.713465971729942,"Lowest cost"]
[null,null,223913.40506325179,211,"G2_TN IE_PR24","G2_TE IE_SOF+RBV12",null,"G3 TE IE_F4SVR","DC_SVRG3",0.77349890084413542,0.16949954051276978,0,4101.5,6731.12,0,14474.83,11.919411753145216,0,null,412,{"$f":"MAX(IF($D$12:$D$406=T24,$C$12:$C$406))","v":203623.8636329346},"G4_TN IE_SMV+PR12+24","G4_TE IE_2D+R12","G4_TE IE_SOF+LED12","G4 TE IE_F4SVR","DC_SVRG1",0.78208735587213019,0.16069492821466222,2.9619949963033613E-3,25506.79,5467.78,121.92,34441.14,11.903250181601107,"Lowest cost"]
[null,null,195502.4058376113,300,"G3_TN III_SOF+LED+R12","G3_TE III_SOF+DCV12",null,"G3 TE III_F4SVR","DC_SVRG3",0.92428132255419326,3.7839689233885761E-2,0,39355.31,2510.15,0,44225.41,11.986390791867699,0]
[null,null,195539.9793890132,300,"G3_TN III_SOF+LED+R12","G3_TE III_SOF+DCV12","G3_TE III_SOF+RBV24","G3 TE III_F4SVR","DC_SVRG3",0.92428132255419326,3.7839689233885761E-2,2.7049620735897059E-3,39355.31,2510.15,238.07,44284.04,11.991200969416449,12188.552170020237]
[null,null,215623.91353189584,310,"G3_TN IE_PR24","G3_TE IE_SOF+PR12","G3_TE IE_SOF+LED+R12","G3 TE IE_F4SVR","DC_SVRG3",0.66364328535652339,0.2079105298463122,4.7546110296117897E-2,4099.3900000000003,9469.67,2201.94,20545.39,11.808465176589609,0]
[null,null,215604.76368660657,310,"G3_TN IE_PR24","G3_TE IE_SOF+LED+R12","G3_TE IE_SOF+PR12","G3 TE IE_F4SVR","DC_SVRG3",0.66364328535652339,0.22897478767995186,2.7087042097892925E-2,4099.3900000000003,10696.03,1224.3399999999999,20740.080000000002,11.817242184316322,22181.488960918705]
[null,null,215183.75187365807,310,"G3_TN IE_PR24","G3_TE IE_SOF+LED+R12","G3_TE IE_SOF+DCV12","G3 TE IE_F4SVR","DC_SVRG3",0.66364328535652339,0.22897478767995186,3.1593693417653411E-2,4099.3900000000003,10696.03,2059.34,21342.51,11.826313093647324,66413.573106844997]
[null,null,196252.50976221965,310,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+PR12","G3_TE IE_SOF+DCV12","G3 TE IE_F4SVR","DC_SVRG3",0.92413117791290877,3.2455482799265564E-2,7.9541323660433996E-3,39352.480000000003,1495.81,523.51,43535.73,11.989411988077951,136072.1657708092]
[null,null,195680.3047569308,310,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+DCV12","G3_TE IE_SOF+PR12","G3 TE IE_F4SVR","DC_SVRG3",0.92413117791290877,3.7950518762196898E-2,2.6305008820680428E-3,39352.480000000003,2518.9899999999998,120.2,44139.38,11.990984237808163,383944.60396458168]
[null,null,195569.39059265971,310,"G3_TN IE_SOF+LED+R12","G3_TE IE_SOF+DCV12","G3_TE IE_SOF+RBV24","G3 TE IE_F4SVR","DC_SVRG3",0.92413117791290877,3.7950518762196898E-2,2.7418252385551364E-3,39352.480000000003,2518.9899999999998,241.52,44253.39,11.991139029606948,736534.49921062728]
[null,null,215623.91353273229,311,"G3_TN IE_PR24","G3_TE IE_SOF+PR12","G3_TE IE_SOF+LED+R12","G3 TE IE_F4SVR","DC_SVRG3",0.66364328535652339,0.2079105298463122,4.7546110296117897E-2,4099.3900000000003,9469.67,2201.94,20545.39,11.808465176589609,0]
[null,null,215604.76368721982,311,"G3_TN IE_PR24","G3_TE IE_SOF+LED+R12","G3_TE IE_SOF+PR12","G3 TE IE_F4SVR","DC_SVRG3",0.66364328535652339,0.22897478767995186,2.7087042097892925E-2,4099.3900000000003,10696.03,1224.3399999999999,20740.080000000002,11.817242184316322,22181.488960918705]
[null,null,215183.75187348734,311,"G3_TN IE_PR24","G3_TE IE_SOF+LED+R12","G3_TE IE_SOF+DCV12","G3 TE IE_F4SVR","DC_SVRG3",0.66364328535652339,0.22897478767995186,3.1593693417653411E-2,4099.3900000000003,10696.03,2059.34,21342.51,11.826313093647324,66413.573106844997]
[null,null,211194.79427490607,311,"G3_TN IE_PR24","G3_TE IE_SOF+DCV12","G3_TE IE_SOF+LED+R12","G3 TE IE_F4SVR","DC_SVRG3",0.66364328535652339,0.24240893923206605,1.8548811052841282E-2,4099.3900000000003,15932.32,859.92,25338.62,11.826670713704493,11174173.875006957]
[null,null,205060.07192215766,400,"G4_TN III_2D+R12","G4_TE III_SOF+LED12",null,"G4 TE III_F4SVR","DC_SVRG1",0.95215737014187274,2.028484047101586E-2,0,32548.07,850.97,0,35283.620000000003,12.017184596076065,0]
[null,null,205078.6896780231,400,"G4_TN III_2D+R12","G4_TE III_SOF+LED12","G4_TE III_SOF+DCV12","G4 TE III_F4SVR","DC_SVRG1",0.95215737014187274,2.028484047101586E-2,1.1414467368848203E-3,32548.07,850.97,71.66,35300.42,12.018955483877505,9485.524710453943]
[null,null,199515.60530365785,400,"G4_TN III_SOF+LED12","G4_TE III_2D+R12","G4_TE III_SOF+DCV12","G4 TE III_F4SVR","DC_SVRG1",0.94971650099854044,2.3421508850760324E-2,4.3896860082212331E-4,38456.400000000001,804.1,27.55,41124.36,12.03199826514386,446526.36435936432]
[null,null,206169.82943493593,410,"G4_TN IE_PR48","G4_TE IE_2D+R12","G4_TE IE_SOF+LED12","G4 TE IE_F4SVR","DC_SVRG1",0.45873492489105433,0.42810845896261779,7.9765315843272205E-3,6431.08,14319.79,322.73,28099.49,11.713465971729942,0]
[null,null,205049.40684869513,410,"G4_TN IE_2D+R12","G4_TE IE_SOF+LED12","G4_TE IE_SOF+PR12","G4 TE IE_F4SVR","DC_SVRG1",0.95167679960644724,2.076998208155122E-2,8.6876977569191524E-4,32554.25,869.5,45.05,35316.339999999997,12.018287342420527,23675.669076777485]
[null,null,205047.01453517179,410,"G4_TN IE_2D+R12","G4_TE IE_SOF+LED12","G4_TE IE_SOF+DCV12","G4 TE IE_F4SVR","DC_SVRG1",0.95167679960644724,2.076998208155122E-2,1.141694775519967E-3,32554.25,869.5,71.599999999999994,35328.74,12.018787726721882,24773.758821788968]
[null,null,199512.66931061202,410,"G4_TN IE_SOF+LED12","G4_TE IE_2D+R12","G4_TE IE_SOF+DCV12","G4 TE IE_F4SVR","DC_SVRG1",0.94975344818240803,2.3387439687825876E-2,4.4081941145991395E-4,38453.279999999999,802.89,27.66,41123.49,12.031807965509808,445057.23699736333]
[null,null,206169.82943479973,411,"G4_TN IE_PR48","G4_TE IE_2D+R12","G4_TE IE_SOF+LED12","G4 TE IE_F4SVR","DC_SVRG1",0.45873492489105433,0.42810845896261779,7.9765315843272205E-3,6431.08,14319.79,322.73,28099.49,11.713465971729942,0]
[null,null,203248.24745880527,411,"G4_TN IE_PR48","G4_TE IE_SOF+LED12","G4_TE IE_2D+R12","G4 TE IE_F4SVR","DC_SVRG1",0.45873492489105433,0.41219570026383767,2.3529053717006015E-2,6431.08,16831,780.43,31109.56,11.717890372933477,680333.28387924982]
[null,null,203623.8636329346,412,"G4_TN IE_SMV+PR12+24","G4_TE IE_2D+R12","G4_TE IE_SOF+LED12","G4 TE IE_F4SVR","DC_SVRG1",0.78208735587213019,0.16069492821466222,2.9619949963033613E-3,25506.79,5467.78,121.92,34441.14,11.903250181601107,0]
[null,null,202504.95357853948,412,"G4_TN IE_SMV+PR12+24","G4_TE IE_SOF+LED12","G4_TE IE_2D+R12","G4 TE IE_F4SVR","DC_SVRG1",0.78208735587213019,0.15468471458126096,8.8283831793463368E-3,25506.79,6426.64,297.85000000000002,35592.43,11.904869178889337,711109.28249858483]
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