ADVERSE EFFECTS IN SYSTEMATIC REVIEWS
Critique of systematic reviews of adverse effects
BackgroundThis systematic review aimed to identify how adverse effects had been dealt with in published systematic reviews identified from DARE and the Cochrane Database of Systematic Reviews (1994-2005). The objective was to review the methodology undertaken in systematic reviews where adverse effects were a primary outcome, and outline any difficulties or gaps in this methodology to inform future research.
There is an obvious need to improve the methodology and reporting of systematic reviews of adverse effects. The methodology around identification and quality assessment of primary data is the main concern.Conducted by: Su Golder1, Yoon Loke2, Heather M McIntosh3
1 Centre for Reviews and Dissemination, University of York; 2 University of East Anglia; 3 Cochrane Infectious Diseases Group
Golder S, Loke Y, McIntosh HM. Poor reporting and inadequate searches were apparent in systematic reviews of adverse effects. J Clin Epidemiol. 2008; 61(5):440-448.
Golder SP, Loke YK, McIntosh HM. Room for improvement? A survey of the methods used in systematic reviews of adverse effects. BMC Med Res Methodol. 2006;6:3Golder SP, McIntosh HM, Loke YK. Identifying systematic reviews of the adverse effects of health care interventions. BMC Med Res Methodol. 2006;6:22
Golder S, Loke Y, McIntosh H. Going beyond MEDLINE: what information might reviewers find from searching databases of adverse drug reactions? 14th Cochrane Colloquium; 2006 October; Dublin, Ireland
Golder S, Loke Y, McIntosh H. How is information on adverse effects identified for systematic reviews? A survey of methods used from 1994-2005. 14th Cochrane Colloquium; 2006 October; Dublin, Ireland
Golder S, McIntosh H, Glanville J. Searching for systematic reviews of adverse effects. 13th Cochrane Colloquium; 2005 October; Melbourne, Australia
Herxheimer A, Marson T, Golder S. Incorporating data on adverse effects in systematic reviews. 13th Cochrane Colloquium; 2005 October; Melbourne, Australia
Loke Y, Golder S, Ashby D. Identifying and incorporating adverse effects in systematic reviews. 14th Cochrane Colloquium; 2006 October; Dublin, IrelandWarren FC, Abrams KR, Sutton AJ, Golder S, Ashby D. Review of statistical methods used in meta-analysis of adverse drug reactions data. International Conference of the Royal Statistical Society; 2007 July; York, UK
No external funding