ADVERSE EFFECTS IN SYSTEMATIC REVIEWS

Critique of systematic reviews of adverse effects

Background

This systematic review aimed to identify how adverse effects had been dealt with in published systematic reviews identified from DARE and the Cochrane Database of Systematic Reviews (1994-2005). The objective was to review the methodology undertaken in systematic reviews where adverse effects were a primary outcome, and outline any difficulties or gaps in this methodology to inform future research.

Findings

There is an obvious need to improve the methodology and reporting of systematic reviews of adverse effects. The methodology around identification and quality assessment of primary data is the main concern.

Conducted by: Su Golder1, Yoon Loke2, Heather M McIntosh3

1 Centre for Reviews and Dissemination, University of York; 2 University of East Anglia; 3 Cochrane Infectious Diseases Group

Publications

Golder S, Loke Y, McIntosh HM. Poor reporting and inadequate searches were apparent in systematic reviews of adverse effects. J Clin Epidemiol. 2008; 61(5):440-448.

Golder SP, Loke YK, McIntosh HM. Room for improvement? A survey of the methods used in systematic reviews of adverse effects. BMC Med Res Methodol. 2006;6:3

Golder SP, McIntosh HM, Loke YK. Identifying systematic reviews of the adverse effects of health care interventions. BMC Med Res Methodol. 2006;6:22

Posters

Golder S, Loke Y, McIntosh H. How is information on adverse effects identified for systematic reviews? A survey of methods used from 1994-2005. 14th Cochrane Colloquium; 2006 October; Dublin, Ireland

Golder S, Duffy S, Glanville, McIntosh HM, Miles J. Designing a search filter to identify reports of adverse events. 2004

Golder S, McIntosh HM, Duffy S, Glanville J. Developing efficient search strategies to identify papers on adverse events. HTAi Annual Meeting 2004. Krakow, Poland, 30 May 2004

Presentations

Golder S, Loke Y, McIntosh H. Going beyond MEDLINE: what information might reviewers find from searching databases of adverse drug reactions? 14th Cochrane Colloquium; 2006 October; Dublin, Ireland

Golder S, McIntosh H, Glanville J. Searching for systematic reviews of adverse effects. 13th Cochrane Colloquium; 2005 October; Melbourne, Australia

Herxheimer A, Marson T, Golder S. Incorporating data on adverse effects in systematic reviews. 13th Cochrane Colloquium; 2005 October; Melbourne, Australia

Loke Y, Golder S, Ashby D. Identifying and incorporating adverse effects in systematic reviews. 14th Cochrane Colloquium; 2006 October; Dublin, Ireland

Warren FC, Abrams KR, Sutton AJ, Golder S, Ashby D. Review of statistical methods used in meta-analysis of adverse drug reactions data. International Conference of the Royal Statistical Society; 2007 July; York, UK

Funding

No external funding