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Andrea Manca
Senior Research FellowEmail: am126@york.ac.uk
Andrea is Senior Research Fellow based in the Team for Economic Evaluation and Health Technology Assessment, part of the Centre for Health Economics at The University of York (UK). He holds a MSc in Health Economics (1998) and a PhD in Economics (2005), both awarded by the University of York.
His research interests include the application of statistical methods for the analysis of cost‑effectiveness and health outcomes data, as well as the use of evidence synthesis techniques for health care decision making.
In 2007 Andrea completed a post‑doctoral Research and Training Fellowship in Health Services Research awarded by The Wellcome Trust, to investigate the use of statistical methods for the analysis of multicentre and multinational individual patient‑level cost‑effectiveness data, where the objective is to inform reimbursement decisions in different jurisdictions. As part of his Fellowship, Andrea spent a six‑month research visiting period at the Institute for Clinical Evaluative Sciences in Toronto (Ontario, Canada).
His work on the analysis of multinational cost-effectiveness data received the ISPOR 2008 Research Excellence Award for Methodology.
In 2009 Andrea was awarded a Career Development Fellowship funded by the National Institute for Health Research (NIHR) titled “Developing economic evaluation methods for decision making: the value of access to individual patient data”. This award provides 3 years full-time funding to individuals who have significant and successful post-doctoral experience.
He has evaluated health technologies in several clinical areas including breast and advanced colorectal cancer, endovascular aneurysm repair, coronary revascularisation, diabetes, neck and chronic low back pain, surgical interventions for urinary stress incontinence, and hysterectomy.
Andrea sits on one of the National Institute of Health Research (NIHR) funding sub-panels, and is a member of the UK Medical Research Council (MRC) College of Experts. He is a member of the faculty of the York Expert Workshops in the Socio Economic Evaluation of Medicines, the York Regression Methods for Health Economic Evaluationcourseand serves as co-editor of the scientific journals Value in Health and Pharmacoeconomics Italian Research Articles.
Andrea’s list of publications can be found here.
Selected publications (last 5 years)
Methodological contributions
Gauthier A, Manca A, Anton S. Bayesian modelling of healthcare resource use in multinational randomised clinical trials. Pharmacoeconomics. 2009;In Press.
Austin PC, Manca A, Zwarenstein M, Juurlink DN, Stanbrook MB. A substantial and confusing variation exists in handling of baseline covariates in randomized controlled trials: a review of trials published in leading medical journals. Journal of Clinical Epidemiology. 2009. In Press.
Manca A, Lambert PC, Sculpher M, Rice N. Cost-effectiveness analysis using data from multinational trials: the use of bivariate hierarchical modelling. Medical Decision Making. 2007;27:471-90. Download here
Manca A, Willan A. "Lost in translation": accounting for between-country differences in the analysis of multinational cost-effectiveness data. Pharmacoeconomics. 2006;24(11):1101-19.
Drummond MF, Manca A, Sculpher MJ. Increasing the generalisability of economic evaluations: recommendations for the design, analysis and reporting of studies. International Journal of Technology Assessment in Health Care 2005;21:165-171. Abstract
Manca A, Hawkins N, Sculpher MJ. Estimating mean QALYs in trial-based cost-effectiveness analysis: the importance of controlling for baseline utility. Health Economics 2005;14:487-496. Abstract
Manca A, Palmer S. Handling missing data in rct-based cost-effectiveness analysis. Applied Health Economics and Health Policy 2005;4:65-75. Abstract
Manca A, Rice N, Sculpher MJ, Briggs AH. Assessing generalisability by location in trial based cost effectiveness analysis: the use of multilevel models. Health Economics 2005;14:471-485. Abstract
Willan AR, Lin DY, Manca A. Regression methods for cost-effectiveness analysis with censored data. Statistics in Medicine 2005;24:131-45. Abstract
Applied research
Manca A, Eldabe S, Buchser E, Kumar K, Taylor RS. Relationship between health related quality of life, pain and functional disability in neuropathic pain patients with failed back surgery syndrome. Value in Health. In Press.
Cooke D, Hurel SJ, Casbard A, Steed L, Walker S, Meredith S, Nunn AJ, Manca A, Sculpher M et al. Randomized controlled trial to assess the impact of continuous glucose monitoring on HbA1c in insulin-treated diabetes (MITRE Study). Diabetic Medicine. 2009;26(5):540-7. Download here
McKenna C, Bojke L, Manca A, et al. Shoulder acute pain in primary healthcare: Is retraining GP's effective (SAPPHIRE) randomised trial - cost effectiveness analysis. Rheumatology. 2009;48(5):558-63.
Iglesias C, Manca A, Torgerson D. The health related quality of life and cost implications of falls in elderly women. Osteoporosis International. 2008;20(6):869-78.
Epstein D, Mason A, Manca A. The hospital costs of care for stroke in nine European countries. Health Economics. 2008;17 (S1):S21-S31. Download here
Manca A, Kumar K, Taylor RS, Jacques L, Eldabe S, Meglio M, et al. Quality of life, resource consumption and costs of spinal cord simulation versus conventional medical management in neuropathic pain patients with failed back surgery syndrome (PROCESS trial). European Journal of Pain. 2008;12:1047-58.
Griffin SC, Barber JA, Manca A, Sculpher M, Thompson SG, Buxton MJ, et al. Cost effectiveness of clinically appropriate decisions on alternative treatments for angina. British Medical Journal. 2007;334(7594):624.
Manca A, Epstein D, Torgerson DL, Klaber Moffett JA, Coulton S, Farrin A, et al. Randomised trial of a brief physiotherapy intervention compared with usual physiotherapy for neck pain patients: a cost-effectiveness analysis. International Journal of Technology Assessment in Health Care 2006;22(1):67-75.
EVAR Trial Participants. Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurism (EVAR trial 1): randomised controlled trial. Lancet 2005;365:2179-86. Abstract
Sculpher M, Manca A, Abbott J, Fountain J, Mason S, Garry R. Cost effectiveness analysis of laparoscopic hysterectomy compared with standard hysterectomy: results from a randomised trial. BMJ 2004;328:134-139. Abstract
UK Beam Trial Team, Russell I, Underwood M, Brealey S, Burton K, Coulton S, et al. United Kingdom back pain exercise and manipulation (UK BEAM) randomised trial: cost effectiveness of physical treatments for back pain in primary care. BMJ 2004;329:1381-1386. Abstract
Last updated August 18, 2009