Professor Anthony J Wilkinson Publications

2010 2009 2008 2007 2006 2005 2004 2003 2002 2001

2010

  • N-myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis.
    J A Brannigan, B A Smith, Z Yu,  A M Brzozowski, M R Hodgkinson, A Maroof, H P Price, F Meier, R J Leatherbarrow,  E W Tate, D F Smith and A J Wilkinson, J. Mol. Biol., 2010, 396, 985-999.
  • pBaSysBioII: an integrative plasmid generating gfp transcriptional fusions for high-throughput analysis of gene expression in Bacillus subtilis.
    E Botella, M Fogg, M Jules, S Piersma, G Doherty, A Hansen, E L Denham, L Le Chat, P Veiga, K Bailey, P J Lewis, J M van Dijl, S Aymerich, A J Wilkinson and K M Devine, Microbiology, 2010, 156, 1600-1608.
  • Structure of the catalytic domain of the human mitochondrial Lon protease: Proposed relation of oligomer formation and activity.
    J García-Nafría, G Ondrovičová, E Blagova, V M Levdikov, J A Bauer, C K Suzuki, E Kutejová, A J Wilkinson and K S Wilson, Protein Science, 2010, 19 987-999.
  • Structural basis for the efficient phosphorylation of AZTMP and dGMP by Plasmodium falciparum type I thymidylate kinase.
    J L Whittingham, J Carrero-Lerida, J A Brannigan, L M Ruiz-Pérez, A P Silva, M J Fogg, A J Wilkinson, I H Gilbert, K S Wilson and D González-Pacanowska, Biochem. J., 2010, 428, 499-509.
  • N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
    J A Frearson, S Brand, S P McElroy, L A Cleghorn, O Smid, L Stojanovski, H P Price, M L Guther, L S Torrie, D A Robinson, I Hallyburton, CP Mpamhanga, J A Brannigan, A J Wilkinson, M Hodgkinson, R Hui, W Qiu, O G Raimi, D M van Aalten, R Brenk, I H Gilbert, K D Read, A H Fairlamb, M A Ferguson, D F Smith and P G Wyatt, Nature, 2010, 464, 728-732.
  • Expression of soluble, active fragments of the morphogenetic protein SpoIIE from Bacillus subtilis using a library-based construct screen.
    A E Rawlings, V M Levdikov, E Blagova, V L Colledge, P J Mas, J Tunaley, L Vavrova, K S Wilson, I Barak, D J Hart and A J Wilkinson, Protein Eng. Des. Sel.,  2010, E-pub ahead of print.
  • Small subunits of RNA polymerase: localisation, levels and implications for core enzyme composition.
    G P Doherty, M J Fogg, A J Wilkinson and P J Lewis, Microbiology, 2010, in press.
  • The Corynebacterium glutamicum Aconitase Repressor: Scratching around for crystals.
    J García-Nafría, M Baumgart, M Bott, A J Wilkinson and K S Wilson, Acta Cryst F, 2010, 66, 1074-1077.
  • Book review: The Selected Papers of Sir Alan Fersht: Development of Protein Engineering.
    A J Wilkinson, Protein Eng. Des. Sel., 2010,  E-pub ahead of print, 2010, doi: 10.1093/protein/gzq103.
  • The structure and interactions of SpoIISA and SpoIISB, a toxin - antitoxin system in Bacillus subtilis.
    P Florek, V M Levdikov, E Blagova, A A Lebedev, R Rostislav, S Rešetárová, P Pavelčíková, I Barak and A J Wilkinson, J. Biol. Chem., 2010, E-pub ahead of print.

2009

  • The structure of Rph, an exoribonuclease from Bacillus anthracis at 1.7 Å resolution.
    A E Rawlings, E V Blagova, V M Levdikov, M J Fogg, K S Wilson and A J Wilkinson, Acta Cryst F, 2009, 65, 2-7.
  • Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages.
    C Schnick, S D Polley, Q L Fivelman, L C Ranford-Cartwright, S R Wilkinson, J A  Brannigan, A J Wilkinson and D A Baker, Mol. Microbiol., 2009, 71, 533-45.
  • Structural rearrangement accompanying ligand binding in the GAF domain of CodY from Bacillus subtilis.
    V M Levdikov, E Blagova, V L Colledge, A A Lebedev, D C Williamson, A L Sonenshein and A J Wilkinson, J. Mol. Biol., 2009, 390, 1007-1018.
  • The crystal structures of human S100A12 in apo form and in complex with zinc: insights into S100A12 oligomerisation.
    O V Moroz, E V Blagova, A J Wilkinson, K S Wilson and I B Bronstein, J. Mol. Biol., 2009, 391, 536-551.
  • The Crystal Structures of Macrophage Migration Inhibition Factor (MIF) from Plasmodium falciparum and Plasmodium berghei.
    S E Dobson K D, Augustijn, J A Brannigan, C Schnick, C J Janse E J Dodson A P Waters and A J Wilkinson, Protein Science, 2009, 18, 2578-2591.
  • Genetic and Biochemical Analysis of the Interaction of Bacillus subtilis CodY With Branched-Chain Amino Acids.
    A C Villapakkam, L D Handke, B R Belitsky, V M Levdikov, A J Wilkinson and A L Sonenshein, J. Bacteriol., 2009, 191, 6865-6876.

2008

  • Functional role for a conserved aspartate in the Spo0A signature motif involved in the dephosphorylation of the Bacillus subtilis sporulation regulator Spo0A.
    A R Diaz, S J Stephenson, M Green, V M Levdikov, A J Wilkinson and M Perego, J. Biol. Chem., 2008, 283, 2962-2972.
  • Lipid spirals in Bacillus subtilis and their role in cell division.
    I Barak, K Muchova, A J Wilkinson, P J O’Toole and N Pavlendova, Mol. Microbiol., 2008, 68, 1315-1327.
  • Higher-throughput approaches to crystallization and crystal structure determination.
    M J Fogg and A J Wilkinson, Biochem. Soc. Trans., 2008, 31, 771-775.

2007

  • Division site recognition in Escherichia coli and Bacillus subtilis.
    I Barak and A J Wilkinson, FEMS Microbiology Reviews, 2007, 31, 311-326.
  • A bacterial virulence factor with a dual role as an adhesin and a solute binding-protein: the crystal structure at 1.5 Å resolution of the PEB1a protein from the food-borne human pathogen Campylobacter jejuni.
    A Müller, M R León-Kempis, E J Dodson, K S Wilson, A J Wilkinson and D J Kelly,/J Mol Biol, 2007, 372, 160-171.

2006

  • Crystal Structure of Dihydrodipicolinate Synthase (BA3935) from Bacillus anthracis at 1.94 Å Resolution.
    E Blagova, V M Levdikov, N V Milioti, M J Fogg, A Kalliomaa, J A Brannigan, K S Wilson and A J Wilkinson, 2006, Prot. Struct. Func. Bioinf., 62, 297-301
  • The GTPase CpgA (YloQ), a putative translation factor, is implicated in morphogenesis in Bacillus subtilis.
    L Cladiere, H Kassem, E Madec, V M Levdikov, A J Wilkinson, I B Holland, and S J Seror, 2006, Mol. Genet. Genomics, 275, 409-420.
  • The structure of CodY, a GTP and isoleucine responsive regulator of stationary phase and virulence in Gram-positive bacteria.
    V M Levdikov, E Blagova, P Joseph, A L Sonenshein, and A J Wilkinson, 2006, J. Biol. Chem. 281, 11366-11373.
  • Gankyrin: a new oncoprotein and regulator of pRb and p53.
    S Dawson, H Higashitsuji, A J Wilkinson, J Fujita, and R J Mayer, 2006, Trends Cell Biol.,
  • The structure of SiaP, a sialic acid-binding virulence factor from Haemophilus influenzae: conservation of structure and mechanism in primary and secondary transporters.
    A Müller, E Severi, C Mulligan, A G Watts, D J Kelly, K S Wilson, A J Wilkinson, and G H J Thomas, 2006, Biol. Chem., 281, 22212-22222 .
  • An [{Fe(mecam)}2]6- bridge in the crystal structure of a ferric enterobactin binding protein.
    A Müller, A J Wilkinson, K S Wilson, and A-K Duhme-Klair, 2006, Angewandte Chemie, 45, 5132-5136.
  • Structural basis of the sulfate starvation response in E. coli : crystal structure and mutational analysis of the cofactor-binding domain of the Cbl transcriptional regulator.
    E Stec, M Witkowska-Zimny, M M Hryniewicz, P Neumann, A J Wilkinson. A M Brzozowski, C S Verma, J Zaim, and G D J Bujacz, 2006, Mol. Biol., 364, 309-322.
  • Structural and biochemical characterisation of a mitochondrial peroxiredoxin from Plasmodium falciparum.
    I B Boucher, P J McMillan , M Gabrielsen, S E Akerman, J A Brannigan, C Schnick, A M Brzozowski, A J Wilkinson, and S Muller, 2006, Mol. Microbiol., 61, 948-959.
  • The crystal structure of superoxide dismutase from Plasmodium falciparum.
    I B Boucher, A M Brzozowski, J A Brannigan, C Schnick, D J Smith, S A Kyes, and A J Wilkinson, 2006, BMC Structural Biology 6:20, doi:10.1186/1472-6807-6-20.
  • Structural characterisation of Spo0E-like protein aspartic acid phosphatases that regulate sporulation in Bacillus anthracis.
    R Grenha, N Rzechorzek, J A Brannigan, R N de Jong, E Ab, T Diercks, V Truffault, J C Ladds, M J Fogg, C Bongiorni, M Perego, R Kaptein, K S Wilson, G E Folkers and A J J Wilkinson, 2006, Biol. Chem., 281, 37993-38003.

2005

  • The structure of the oligopeptide-binding protein, AppA, from Bacillus subtilis in complex with a nonapeptide.
    V M Levdikov, E Blagova, J A Brannigan, L Wright, A A Vagin, and A J J Wilkinson, 2005, Mol. Biol., 345, 879-892.
  • dUTPase as a platform for anti-malarial drug design: structural basis for the selectivity of a new class of nucleoside inhibitors.
    J L Whittingham, I Leal, C Nguyen, G Kasinathan, E Bell, A F Jones, C Berry, A Benito, J P Turkenburg, E J Dodson, L M Ruiz-Perez, A J Wilkinson, N G Johansson, R Brun, I H Gilbert, D Gonzalez-Pacanowska, and K S Wilson, 2005, Structure, 13, 329-338.
  • Structure of purine nucleotide phosphorylase (DeoD) from Bacillus anthracis.
    R Grenha, V M Levdikov, M J Fogg, E V Blagova, J A Brannigan, A J Wilkinson, and K S Wilson, 2005, Acta Crystallogr., F61 459-462.
  • Crystal structures of the Plasmodium falciparum Purine Nucleoside Phosphorylase: unliganded and in complex with its natural substrate inosine
    C Schnick, M A Robien, A M Brzozowski, G N Murshudov, E J Dodson, W G J Hol, J A Brannigan, and A J Wilkinson, 2005, Acta Crystallogr., D61, 1245-1254.
  • Crystal Structure of PurE (BA0288) from Bacillus anthracis at 1.8 Å Resolution.
    M P Boyle, A Kalliomaa, E Blagova, M Fogg, V Levdikov, J A Brannigan, K S Wilson and A J Wilkinson, 2005, Prot. Struct. Func. & Bioinf., 61, 674-676.
  • Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre.
    I W Boucher, A K Kalliomaa, V M Levdikov, E Blagova, M J Fogg, J A Brannigan, K S Wilson and A J Wilkinson, 2005, Acta Crystallogr., F61, 621-624.
  • The structure of Bypass of Forespore C, an inter-compartmental signalling factor in sporulation in Bacillus
    H M Patterson, J A Brannigan, S M Cutting, K S Wilson, A J Wilkinson, E Ab, T Diercks, G Folkers, R de Jong, R., V Truffault and R J Kaptein. 2005, Biol. Chem., 280, 36214-36220.
  • Where asymmetry in gene expression originates.
    I Barak, and A J Wilkinson, 2005, Mol. Microbiol., 57, 611-620.
  • An ABC-type cysteine transporter in Campylobacter jejuni inferred form the structure of an extracytoplasmic solute receptor protein.
    A Muller, G H Thomas, R Horler, J A Brannigan, E Blagova, V M Levdikov, M J Fogg, K S Wilson, and A J Wilkinson, 2005, Mol. Microbiol., 57, 143-155.

2004

  • The crystal structure of gankyrin, an oncoprotein found in complexes with CDK4, a 19S proteasomal ATPase regulator and the tumour suppressors Rb and p53.
    S Krzywda, A M Brzozowski, H Higashitsuji, J Fujita, R Welchman, S Dawson, R J Mayer, and A J Wilkinson, 2004, J. Biol. Chem., 279, 1541-1545.
  • Crystallisation of YloQ, a GTPase of Unknown Function Essential for Bacillus subtilis Viability.
    L Cladière, E Blagova, V M Levdikov, J A Brannigan, S J Séror, A J Wilkinson, 2004, Acta Crystallogr., D60, 329-330.
  • Crystallisation of the oligopeptide-binding Protein AppA from Bacillus subtilis.
    L Wright, E Blagova, V M Levdikov, J A Brannigan, R J Pattenden, J Chambers and A J Wilkinson, 2004, Acta Crystallogr., D60, 175-177.
  • "Sulphide: Biosynthesis from Sulphate."
    K H G Verschueren and A J Wilkinson, in Nature Encyclopedia of Life Sciences, Macmillan, London 2004.
  • Residues in the Distal Heme Pocket of Neuroglobin: Implications for the Multiple Ligand Binding Steps.
    T Uno, D Ryu, H Tsutsumi, Y Tomisugi, Y Ishikawa, A J Wilkinson, H Sato, and T J Hayashi, 2004, Biol. Chem., 279, 5886-5893.
  • Oligomeric structure of the Bacillus subtilis cell division protein DivIVA determined by transmission electron microscopy.
    H Stahlberg, E Kutejová, K Muchová, M Gregorini, A Lustig, S A Müller, V Olivieri, A Engel, A J Wilkinson, and I Barák, 2004, Mol. Microbiol., 52, 1281-1290.
  • Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases.
    T Ogura, S W Whiteheart, and A J Wilkinson, 2004, J. Struct. Biol., 146, 106-112.
  • Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting insulins.
    J L Whittingham, I Jonassen, S Havelund, S M Roberts, E J Dodson, C S Verma, A J Wilkinson and G G Dodson, 2004, Biochemistry, 43, 5987-5995.
  • Dimer induced signal propagation in Spo0A.
    K Muchová, R J Lewis, D Pere_ko, J A Brannigan, J C Ladds, A Leech, A J Wilkinson, and I Barák, 2004, Mol. Microbiol. 53, 829-842.
  • The Crystal Structure of YloQ, a circularly permuted GTPase Essential for Bacillus subtilis Viability.
    V M Levdikov, E Blagova, J A Brannigan, L Cladière, A A Antson, M N Isupov, S J Séror, and A J Wilkinson, 2004, J. Mol. Biol., 340, 767-782.
  • Crystallisation and preliminary crystallographic studies of the cofactor-binding domain of the LysR-type transcriptional regulator Cbl from Escherichia coli.
    E Stec, M Witkowska, M M Hryniwicz, A M Brzozowski, A J Wilkinson. 2004, Acta Crystallogr., D60, 1654-1657.

2003

  • Crystal Structures of Periplasmic Solute Binding Proteins in ABC-Transport Complexes Illuminate their Function.
    A J Wilkinson, and K H G Verschueren, in "ABC transporters from Bacteria to Man" ed. I B Holland, K Kuchler, C F Higgins and S Cole Academic Press, London, UK, 2003, 187-208.
  • Crystallisation of the GTP-dependent transcriptional regulator CodY from Bacillus subtilis.
    E V Blagova, V M Levdikov, K Tachikawa, A L Sonenshein, and A J Wilkinson, 2003, Acta Crystallogr., D59, 155-157.
  • The response regulator Spo0A from Bacillus subtilis is efficiently phosphorylated in Escherichia coli.
    J C Ladds, K Muchova, D Blaskovic, R J Lewis, J A Brannigan, A J Wilkinson, and I Barak, 2003, FEMS Microbiol. Lett. 223, 153-157.
  • Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b (rpt3) ATPase of the 19S regulator of the 26S proteasome.
    S Krzywda, A M Brzozowski, R Al-Safty, R Welchman, M Mee, S Dawson, J Fujita, H Higashitsuji, R J Mayer and A J Wilkinson, 2003, Acta Crystallogr., D59, 1294-1295.
  • Inversion of Axial Coordination in Myoglobin to Create a "Proximal" Ligand Binding Pocket.
    T Uno, R Sakamoto, Y Tomisugi, Y Ishikawa and A J Wilkinson, 2003, Biochemistry 42, 10191-10199.

2002

  • Oligomerization of the Bacillus subtilis division protein DivIVA.
    K Muchová, E Kutejová, D J Scott, J A Brannigan, R J Lewis, A J Wilkinson, and I Barák, 2002, Microbiology 148, 807-813.
  • Dimer formation and transcription activation in the sporulation response regulator Spo0A.
    R J Lewis, D J Scott, J A Brannigan, J C Ladds, M A Cervin, G B Spiegelman, J G Hoggett, I Barak and A J Wilkinson 2002, J. Mol. Biol., 316, 235-245.
  • Crystallization of the AAA domain of the ATP-Dependent Protease FtsH of Escherichia coli.
    S Krzywda, A M Brzozowski, K Karata, T Ogura, and A J Wilkinson, 2002, Acta Crystallogr., D58, 1066-1067.
  • The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 Å resolution.
    S Krzywda, A M Brzozowski, K Karata, T Ogura, and A J Wilkinson, 2002, Structure, 10, 1073-1083.
  • Protein engineering twenty years on.
    J A Brannigan and A J Wilkinson, 2002, Nature Rev. Mol. Cell. Biol. 3, 8-14.

2001

  • Crystallization and preliminary X-ray analysis of the sporulation factor SpoIIAA in its native and phosphorylated forms.
    P R Seavers, R J Lewis, J A Brannigan, and A J Wilkinson, 2001, Acta Cryst, D57 292-295.
  • Probing the mechanism of ATP hydrolysis and substrate translocation in the AAA protease FtsH by modeling and mutagenesis.
    K Karata, C V Verma, A J Wilkinson, and T Ogura, 2001, Mol. Microbiol., 39, 890-903.
  • Crystallization of full-length CysB of Klebsiella aerogenes, a LysR-type transcriptional regulator.
    K H G Verschueren, C Addy, E J Dodson and A J Wilkinson, 2001, Acta Cryst, D57, 260-262.
  • Crystal structure of GerE the ultimate transcriptional regulator of spore formation in Bacillus subtilis.
    V M-A Ducros, R J Lewis, E J Dodson, J P Turkenburg, G Leonard, A J Wilkinson and J A Brannigan, 2001, J. Mol. Biol., 306, 759-771.
  • Engineering a Ligand Binding Pocket into a Four Helix Bundle Protein Cytochrome b562.
    T Uno, A Yukinari, Y Moriyama, Y Ishikawa, Y Tomisugi, J A Brannigan, and A J Wilkinson, 2001, J. Am. Chem. Soc., 123, 512-513.
  • Cysteinate thiolate coordination in the ferrous CO complex of an engineered Cytochrome b562.
    T Uno, A Yukinari, Y Tomisugi, Y Ishikawa, R Makino, J A Brannigan, and A J Wilkinson, 2001, J. Am. Chem. Soc., 123, 2458-2459.
  • Structure of the Bacillus cell fate determinant SpoIIAA in phosphorylated and unphosphorylated forms.
    P R Seavers, R J Lewis, J A Brannigan, H H G Verschueren, G N Murshudov and A J Wilkinson, 2001, Structure, 9, 605-614.
  • AAA+ superfamily ATPases: common structure - diverse function.
    T Ogura and A J Wilkinson, 2001, Genes to Cells, 6, 575-597.
  • Lessons and questions from the structure of the Spo0A activation domain: Response.
    R J Lewis, J A Brannigan, I Barak, and A J Wilkinson, 2001, Trends Microbiol., 9, 150-151.
 
Tony Wilkinson

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