Professor Anthony J Wilkinson

01904 328261
Email: tony.wilkinson@york.ac.uk

Structure and Function of Proteins

My research interests concern structure-function relationships in proteins centred around the techniques of protein engineering and protein crystallography. The ability to introduce specific amino acid alterations in proteins has given the biological chemist/biochemist a powerful method for altering protein function and dissecting mechanism. This power is given precision by high resolution protein structures determined by X-ray crystallography and analysed using molecular graphics and modelling. Facilities exist for employing each of these techniques in the Protein Group at York.

Selected Publications

  • Levdikov, VM, Blagova, EV, McFeat, A, Fogg, MJ, Wilson, KS and Wilkinson, AJ.
    Structure of Components of an Intercellular Channel Complex in Sporulating Bacillus subtilis. Proc. Natl. Acad. Sci. USA 109, 5441-5445 (2012).
  • Nicolas P, Mäder U, Dervyn E, Rochat T, Leduc A, Pigeonneau N, Bidnenko E, Marchadier E, Hoebeke M, Aymerich S, Becher D, Bisicchia P, Botella E, Delumeau O, Doherty G, Denham EL, Fogg MJ, Fromion V, Goelzer A, Hansen A, Härtig E, Harwood CR, Homuth G, Jarmer H, Jules M, Klipp E, Le Chat L, Lecointe F, Lewis P, Liebermeister W, March A, Mars RA, Nannapaneni P, Noone D, Pohl S, Rinn B, Rügheimer F, Sappa PK, Samson F, Schaffer M, Schwikowski B, Steil L, Stülke J, Wiegert T, Devine KM, Wilkinson AJ, van Dijl JM, Hecker M, Völker U, Bessières P, Noirot P.
    Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis. Science  335, 1103-1106 (2012).
  • Levdikov, V.M., Blagova, E.V., Rawlings, A.E., Jameson, K., Tunaley, J., Hart, D.J., Barak, I., Wilkinson, A.J.
    Structure of the Phosphatase Domain of the Cell Fate Determinant SpoIIE from Bacillus subtilis. J. Mol. Biol. 415, 343-358 (2012).
  • Maqbool, A., Levdikov, V. M., Blagova, E., Herve, M., Horler, R. S., Wilkinson, A. J. and Thomas, G. H.
    Compensating stereochemical changes allow murein tripeptide to be accommodated in a conventional peptide binding protein. J. Biol. Chem.  286, 31512-31521 (2011).
  • Brannigan, J. A., Smith, B. A., Yu,  Z., Brzozowski, A. M., Hodgkinson, M. R., Maroof, A., Price, H. P., Meier, F., Leatherbarrow,  R. J., Tate Edward W., Smith, D. F. and Wilkinson A.J.
    N-myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis. J. Mol. Biol. 396, 985-999 (2010).
  • Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG.
    N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.  Nature 464, 728-732 (2010).