Professor Anthony J Wilkinson

01904 328261
Email: ajw@ysbl.york.ac.uk

Structure and Function of Proteins

My research interests concern structure-function relationships in proteins centred around the techniques of protein engineering and protein crystallography. The ability to introduce specific amino acid alterations in proteins has given the biological chemist/biochemist a powerful method for altering protein function and dissecting mechanism. This power is given precision by high resolution protein structures determined by X-ray crystallography and analysed using molecular graphics and modelling. Facilities exist for employing each of these techniques in the Protein Group at York.

Selected Publications

  • The structure of the oligopeptide-binding protein, AppA, from Bacillus subtilis in complex with a nonapeptide.
    V M Levdikov, E Blagova, J A Brannigan, L Wright, A A Vagin and A J Wilkinson, J. Mol. Biol., 2005, 345, 879-892.
  • An ABC-type cysteine transporter in Campylobacter jejuni inferred form the structure of an extracytoplasmic solute receptor protein.
    A Muller, G H Thomas, R Horler, J A Brannigan, E Blagova, V M Levdikov, M J Fogg, K S Wilson and A J Wilkinson, Mol. Microbiol., 2005, 57, 143-155.
  • The structure of CodY, a GTP and isoleucine responsive regulator of stationary phase and virulence in Gram-positive bacteria.
    V M Levdikov, E Blagova, P Joseph, A L Sonenshein and A J Wilkinson, J. Biol. Chem., 2006, 281, 11366-11373.
  • An [{Fe(mecam)}2]6– bridge in the crystal structure of a ferric enterobactin binding protein.
    A Müller, A J Wilkinson, K S Wilson and A-K Duhme-Klair, Angewandte Chemie, 2006, 45, 5132-5136.
  • Structural and biochemical characterisation of a mitochondrial peroxiredoxin from Plasmodium falciparum.
    I B Boucher, P J McMillan, M Gabrielsen, S E Akerman, J A Brannigan, C Schnick, A M Brzozowski, A J Wilkinson and S Muller, Mol. Microbiol., 2006, 61, 948-959.
  • Structural characterisation of Spo0E-like protein aspartic acid phosphatases that regulate sporulation in Bacillus anthracis.
    R Grenha, N Rzechorzek, J A Brannigan, R N de Jong, E Ab, T Diercks, V Truffault, J C Ladds, M J Fogg, C Bongiorni, M Perego, R Kaptein, K S Wilson, G E Folkers and A J Wilkinson, J. Biol. Chem., 2006, 281, 37993-38003.