Dr Anne-Kathrin Duhme-Klair

01904 432587
Email: akd1@york.ac.uk

Metal Ions in Biology and Medicine

Metal ions, such as Fe(III), Ni(II) and Mo(VI), play a fundamental role in biological processes, including electron transfer, oxygen transport and catalysis. In this context we are interested in the strategies used by nature to accumulate these essential metal ions and to tune their reactivity.

Once these strategies are understood they can be applied to other areas of co-ordination chemistry, such as:

Selected Publications

  1. The Iron-Binding Properties of Aminochelin, the Mono(catecholamide) Siderophore of Azotobacter vinelandii.
    H H Khodr, R C Hider and A-K Duhme-Klair, J Biol Inorg Chem, 2002, 7, 891.
  2. A [{Fe(mecam)}2]6- Bridge in the Crystal Structure of a Ferric Enterobactin Binding Protein.
    A Müller, A J Wilkinson, K S Wilson and A-K Duhme-Klair, Angew Chem, Int Ed, 2005, 45, 5132.
  3. Selective Signalling of Molybdate by a Siderophore Derivative.
    S B Jedner, R James, R N Perutz and A-K Duhme-Klair, J Chem Soc, Dalton Trans, 2001, 2327.
  4. A Metal-based Lumophore Tailored to Sense Biologically Relevant Oxometalates.
    A F A Peacock, H D Batey, C Raendler, A C Whitwood, R N Perutz, A-K Duhme-Klair, Angew Chem, Int Ed, 2005, 44, 1576.
  5. Intermolecular Sensitization of a Terbium-containing Amphiphile by an Integral Membrane Protein.
    C L Davies, N G Housden and A-K Duhme-Klair, Angew. Chem., Int. Ed. Engl., 47,2008, 8856.
  6. Enantioselectivity in the Formation of a Cyclic Trinuclear cis-Dioxomolybdenum(VI) Complex of a Chiral Siderophore Analogue.
    A-K Duhme-Klair, G Vollmer, C Mars and R Fröhlich, Angew Chem Int Ed, 2000, 39, 1626.
  7. The First μ6-Peroxide Transition-metal Complex: [Ni8(L)12(O2)]2+.
    E J Brown, A-K Duhme-Klair, M I Elliott, J E Thomas-Oates, P L Timmins and P H Walton, Angew Chem, Int Ed, 2005, 44, 1392.