Profile

Biography

Andrea is a Senior Research Fellow in the Team for Economic Evaluation and Health Technology Assessment, part of the Centre for Health Economics.  He is co-editor of the journal Value in Health and senior associate editor of Pharmacoeconomics Italian Research Articles.  Andrea’s research interests focus on the application of statistical methods for the analysis of cost‑effectiveness and health outcomes data, as well as the use of evidence synthesis techniques for healthcare decision making.  He has evaluated health technologies in several clinical areas including breast and advanced colorectal cancer, endovascular aneurysm repair, coronary revascularisation, diabetes, neck and chronic low back pain, surgical interventions for urinary stress incontinence, and hysterectomy. 

Andrea holds an MSc in Health Economics (1998) and a PhD in Economics (2005), both awarded by the University of York.  In 2007 he completed a post‑doctoral Research and Training Fellowship in Health Services Research awarded by The Wellcome Trust, to investigate the use of statistical methods for the analysis of multicentre and multinational individual patient‑level cost‑effectiveness data, where the objective is to inform reimbursement decisions in different jurisdictions.  As part of his Fellowship, Andrea spent a six‑month research visiting period at the Institute for Clinical Evaluative Sciences in Toronto (Ontario, Canada).   

His work on the analysis of multinational cost-effectiveness data received the ISPOR 2008 Research Excellence Award for Methodology. 

In 2009 Andrea was awarded a Career Development Fellowship funded by the National Institute for Health Research (NIHR) titled “Developing economic evaluation methods for decision making: the value of access to individual patient data”.   

Andrea is currently a member of the NICE Technology Appraisal Committee, the National Institute of Health Research (NIHR) Programme Grants for Applied Research funding sub-panel, and the National Awareness and Early Diagnosis (NAEDI) Research Workstream scientific committee of the Cancer Research-UK.      

Research

Overview

• Statistical methods for the analysis of individual patient-level data
• Quantitative evidence synthesis for health care decision-making
• Regression methods for the analysis of health-related quality of life data
• Bayesian methods in health care evaluation
• Multilevel (hierarchical) modelling

Research group(s)

• Economic evaluation of health technologies
  

Grants

• MRC/NIHR Methodology
  Methods of extrapolating RCT evidence for use in economic evaluation models (2010-2012)
• NIHR
  Career Development Fellowship (2010-2013)
• European Union EuroVaQ
  European Value of a Quality Adjusted Life Year (lead: Newcastle University, UK )
• MRC
  MSc + PhD Capacity Building Grant (2008-2012)
• NIHR
  Spinal cord stimulation in refractory angina (pilot study)

Supervision

• Thomas Patton
• Ronan Mahon
• Pedro Goncalves Saramago
• Manuel Espinoza
  

Publications

Full publications list

Forthcoming and in press

• Conigliani C, Manca A, Tancredi A. Statistical methods for health care economic evaluation. In: Faltin F, Kenett R, Ruggeri F, editors. Statistics in Healthcare Practice: Wiley; 2011: In Press. 
• Saramago P, Manca A, Sutton AJ. Deriving input parameters for cost-effectiveness modelling: taxonomy of data types and approaches to their statistical synthesis. Value in Health 2012;Forthcoming.
• Saramago P, Sutton A, Cooper NJ, Manca A. Mixed treatment comparisons using aggregate- and individual-participant level data statistics in medicine Statistics in Medicine;Forthcoming.

2012

• Basu A, Manca A. Regression estimators for generic health-related quality of life and quality-adjusted life years. Medical Decision Making 2012;32(1):56-69.
• Manca A, Asseburg C, Bravo-Vergel Y, Seymour MT, Meade A, Stephens R, Parmar M, Sculpher MJ. The cost-effectiveness of different chemotherapy strategies for patients with poor prognosis advanced colorectal cancer (MRC FOCUS). Value in Health 2012;15(1):22-31.  

2011

• Campbell HE, Epstein D, Bloomfield D, Griffin S, Manca A, Yarnold J, Bliss J, Johnson L, Earl H, Poole C, Hiller L, Dunn J, Hopwood P, Barrett-Lee P, Ellis P, Cameron D, Harris AL, Gray AM, Sculpher MJ. The cost-effectiveness of adjuvant chemotherapy for early breast cancer: a comparison of no chemotherapy and first, second, and third generation regimens for patients with differing prognoses. European Journal of Cancer 2011;Nov 47(17):2517-30. Download from Sciencedirect
• Kolosa K, Manca A, Schubert S. A review of Health Technology Assessment (HTA) recommendations for drug therapies issued between 2007 and 2009 and their impact on policy making processes in Poland. Health Policy 2011;102(2-3):145-151.

2010

• Manca A, Eldabe S, Buchser E, Kumar K, Taylor RS. Relationship between health-related quality of life, pain, and functional disability in neuropathic pain patients with failed back surgery syndrome. Value in Health 2010;13(1):95-102.
• Manca A, Sculpher M, Goeree R. The analysis of multinational cost effectiveness data for reimbursement decisions: a critical appraisal of recent methodological developments. Pharmacoeconomics 2010;28:1079-96.
• Paton F, Paulden M, Saramago P, Manca A, Misso K, Palmer S, Eastwood A. Topotecan for the treatment of recurrent and stage IVB carcinoma of the cervix. Health Technology Assessment, 2010;14(S1):55-62.
• Conigliani C, Tancredi A, Manca A. Bayesian methods for healthcare decisions (in Italian). Pharmacoeconomics (Italian Research Articles),2010;12(1):1-4.
• Turnbull LW, Brown SR, Olivier C, Harvey I, Brown J, Drew P, Hanby A, Manca A, Napp V, Sculpher M, Walker LG, Walker S.  Multicentre randomised controlled trial examining the cost-effectiveness of contrast-enhanced high field magnetic resonance imaging in women with primary breast cancer scheduled for wide local excision (COMICE). Health Technology Assessment, 2010;14(1):1-182.
• Newman SP, Cooke D, Casbard A, Walker S, Meredith S, Nunn A, Steed L, Manca A, Sculpher M, Barnard M, Kerr D, Weaver J, Ahlquist J, Hurel SJ. A randomised controlled trial to compare minimally invasive glucose monitoring devices with conventional monitoring in the management of insulin-treated diabetes mellitus (MITRE). Health Technology Assessment 2009;13(28):1-216.
• Austin PC, Manca A, Zwarenstein M, Juurlink DN, Stanbrook MB. A substantial and confusing variation exists in handling of baseline covariates in randomized controlled trials: a review of trials published in leading medical journals. Journal of Clinical Epidemiology 2010;63(2):142-53.

2009

• Cooke D, Hurel SJ, Casbard A, Steed L, Walker S, Meredith S, Nunn AJ, Manca A , Sculpher M et al. Randomized controlled trial to assess the impact of continuous glucose monitoring on HbA1c in insulin-treated diabetes (MITRE Study). Diabetic Medicine. 2009;26(5):540-7. Download from Wiley Inter Science
• Gauthier A, Manca A, Anton S. Bayesian modelling of healthcare resource use in multinational randomised clinical trials. Pharmacoeconomics. 2009;27(12):1017-29.
• Augustovski F, Iglesias CP, Manca A, Drummond M, Rubinstein A, García Martí S.  Generalisability of health economic evaluations in Latin America and the Caribbean Region, Pharmacoeconomics 2009;27(11):919-29.
• McKenna C, Bojke L, Manca A, Adebajo A, Dickson J, Helliwell P, Morton V, Russell I, Torgerson D, Water J. Shoulder acute pain in primary healthcare: is retraining GP's dffective (SAPPHIRE) randomised trial - cost effectiveness analysis. Rheumatology 2009;48(5):558-63.
• Manca A. Task Force report on good research practices on economic data transferability in HTA (Editorial). Value in Health 2009;12(4):407.
• Manca A. Economic evaluation of medical devices and drugs - same or different? (Editorial). Value in Health 2009;12(4):401.
• Iglesias C, Manca A, Torgerson D. The health related quality of life and cost implications of falls in elderly women Osteoporosis International 2009;20(6):869-78.

2008

• Manca A, Kumar K, Taylor RS, Jacques L, Eldabe S, Meglio M, Molet J, Thomson S, O'Callaghan J, Eisenberg E, Milbouw G, Buchser E, Fortini G, Richardson J, Taylor RJ, Goeree R, Sculpher M. Quality of life, resource consumption and costs of spinal cord simulation versus conventional medical management in neuropathic pain patients with failed back surgery syndrome (PROCESS trial). European Journal of Pain 2008;12(8):1047-58.
• Epstein D, Mason A, Manca A. The hospital costs of care for stroke in nine European countries. Health Economics . 2008;17 (S1):S21-S31. Download from Wiley Inter Science
• Epstein D, Sculpher MJ, Manca A, Michaels J, Thompson SG, Brown LC, Powell JT, Buxton MJ, Greenhalgh RM.   Endovascular repair versus open repair in patients with abdominal aortic aneurysm: a modelling study to estimate long term cost-effectiveness. British Journal of Surgery 2008;17(95(2)):183-190. 

 2007

• Griffin SC, Barber JA, Manca A, Sculpher M, Thompson SG, Buxton MJ, Hemingway H. Cost effectiveness of clinically appropriate decisions on alternative treatments for angina. British Medical Journal 2007;334(7594):624.
• Cicchetti A, Manca A, Ruggeri M.  L'utilizzo di modelli decisionali per le valutazioni economiche dei farmaci in Italia: stato dell'arte e prospettive future, Pharmacoeconomics (Italian Articles) 2007;9(2):59-74.
• Manca A , Dumville J, Torgerson DJ, Klaber Moffett JA, Mooney MP, Jackson DA, Eaton S.  Randomised trial of two physiotherapy interventions for primary care back and neck pain patients: cost-effectiveness analysis, Rheumatology 2007;46(9):1495-501.
• Goeree R, Burke N, O'Reilly D, Manca A, Blackhouse G, Tarride JE. Transferability of economic evaluations: approaches and factors to consider when using results from one geographic area for another. Current Medical Research and Opinion 2007; 23(4):671-682.
• Manca A, Lambert PC, Sculpher M, Rice N. Cost-effectiveness analysis using data from multinational trials: the use of bivariate hierarchical modelling. Medical Decision Making 2007;27(4):471-90.

2006

• Dumville J, Manca A, Kitchener HC, Smith RB, Nelson L, Torgerson DJ, on behalf of the COLPO study group.  Cost-effectiveness analysis of open colposuspension versus laparoscopic colposuspension in the treatment of urodynamic stress incontinence. British Journal of Obstetrics and Gynaecology 2006;113:1014-1022.
• Manca A, Willan A. "Lost in translation": accounting for between-country differences in the analysis of multinational cost-effectiveness data. Pharmacoeconomics 2006;24(11):1101-19.
• Urdahl H, Manca A, Sculpher MJ.  Assessing generalisability in model-based economic evaluation studies: a structured review in osteoporosis, Pharmacoeconomics 2006;24(12):1181-97.
• Manca A, Epstein D, Torgerson D, Klaber Moffett J, Coulton S, Farrin A, Hahn S, Jackson DA, Richmond S. Randomised trial of a brief physiotherapy intervention compared with usual physiotherapy for neck pain patients: a cost-effectiveness analysis. International Journal of Technology Assessment in Health Care 2006;22(1):67-75.

2005

• Manca A, Palmer S. Handling missing data in RCT-based cost-effectiveness analysis. Applied Health Economics and Health Policy 2005;4(2):65-75.
• EVAR Trial Participants. Endovascular Aneurysm Repair and Outcome in Patients Unfit for Open Repair of Abdominal Aortic Aneurism (EVAR Trial 2): Randomised Controlled Trial. The Lancet 2005; 365(9478): 2187-92.
• EVAR Trial Participants.  Endovascular Aneurysm Repair Versus Open Repair in Patients With Abdominal Aortic Aneurism (EVAR Trial 1): Randomised Controlled Trial. The Lancet 2005; 365(9478); 2179-86.
• Manca A, Hawkins N, Sculpher MJ. Estimating mean QALYs in trial-based cost-effectiveness analysis: the importance of controlling for baseline utility. Health Economics 2005;14:487-496. 
• Manca A, Rice N, Sculpher MJ, Briggs AH. Assessing generalisability by location in trial based cost effectiveness analysis: the use of multilevel models. Health Economics 2005;14:471-485. 
• Drummond MF, Manca A, Sculpher MJ. Increasing the generalisability of economic evaluations: recommendations for the design, analysis and reporting of studies. International Journal of Technology Assessment in Health Care 2005;21:165-171. 
• Klaber Moffett JA, Jackson DA, Richmond SJ, Hahn S, Coulton S, Farrin A, Manca A, Torgerson DJ. Randomised trial of a brief physiotherapy intervention compared with usual physiotherapy for neck pain patients: outcomes and patient preference, British Medical Journal 2005;  330 (7482): 75-80.
• Willan AR, Lin DY, Manca A. Regression methods for cost-effectiveness analysis with censored data. Statistics in Medicine 2005;24:131-45. 

2004

• BEAM Trial Investigators, UK Back Pain Exercise and Manipulation (UKBEAM) randomised trial: cost effectiveness of physical treatments for back pain in primary care. BMJ 2004;329(7479):1381-86.
• BEAM Trial Investigators, UK Back Pain Exercise and Manipulation (UKBEAM) randomised trial: effectiveness of physical treatments for back pain in primary care. BMJ 2004;329(7479):1377-84.
• Richardson G, Manca A. Calculation of quality adjusted life years in the published literature: a review of methodology and transparency. Health Economics 2004;13(12):1203-10.
• Sculpher MJ, Pang FS, Manca A, Drummond MF, Golder S, Urdahl H, Davies LM, Eastwood A. Generalisability in economic evaluation studies in healthcare: a review and case studies. Health Technology Assessment 2004;8(49):1-206.
• Garry R, Fountain J, Brown J, Manca A, Mason S, Sculpher M, Napp V, Bridgman S, Gray J, Lilford R. EVALUATE hysterectomy trial: a multicentre randomised trial comparing abdominal, vaginal and laparoscopic methods of hysterectomy. Health Technology Assessment 2004;8(26):1-154.
• Brown LC, Epstein D, Manca A, Beard JD, Powell JT, Greenhalgh RM. The UK Endovascular Aneurysm Repair (EVAR) Trials: design, methodology and progress. European Journal of Vascular and Endovascular Surgery 2004;27(4):372-81.
• Sculpher M, Manca A, Abbott J, Fountain J, Mason S, Garry R. Cost effectiveness analysis of laparoscopic hysterectomy compared with standard hysterectomy: results from a randomised trial. BMJ 2004;328(7432):134-39.

2003

• Manca A, Sculpher MJ, Ward K, Hilton P. A cost-utility analysis of tension-free vaginal tape versus colposuspension for primary urodynamic stress incontinence. BJOG: An International Journal of Obstetrics and Gynaecology 2003;110(3):255-62.
• Cunningham SJ, Sculpher M, Sassi F, Manca A. A cost-utility analysis of patients undergoing orthognathic treatment for the management of dentofacial disharmony. British Journal of Oral and Maxillofacial Surgery 2003;41(1):32-35.
• Ginnelly L, Manca A. The use of decision models in mental health economic evaluation: challenges and opportunities. Applied Health Economics and Health Policy 2003;2(3):157-64.
• Manca A, Sculpher MJ. Levonorgestrel-releasing intrauterine system for menorrhagia improved quality of life but cost less than hysterectomy. Commentary. Evidence-Based Obstetrics and Gynaecology 2002;4(1):24-5.

2001

• Manca A, Davies LM, Burns A. The cost-effectiveness of therapeutics for Alzheimer's disease, Psychopharmacology: The fifth Generation of Progress. Lippincott Williams & Wilkins (book chapter);2001.
• Davies LM, Manca A. The pharmacoeconomic aspects of dementia Pharmacoeconomics in Psychiatry. Martin Dunitz  (book chapter);2001.

1999

• Manca A, Davies LM. An economic analysis of the management of alzheimer's disease in the UK. The Journal of British Menopause Society 1999;4(5):167-73.

Teaching

Other teaching

 Centre for Health Economics

• The York Regression Methods for Health Economic Evaluation - Course leader and faculty
• The York Expert Workshops in the Socio Economic Evaluation of Medicines - Faculty and tutor
• Advanced Modelling Methods for Health Economic Evaluation - Tutor

External activities

Memberships

• UK Health Economics Study Group 
  member
• International Health Economics Association
  member
• Italian Health Economics Association
  member
• International Society for Pharmacoeconomics and Outcomes Research (ISPOR)
  member
• NIHR – Programme Grant for Applied Research
  committee member
• CRUK - National Awareness and Early Diagnosis Research Workstream
  committee member
• National Institute for Health and Clinical Excellence
  Member of the Technology Appraisal Committee

Editorial duties

• Value in Health
  Co-editor
• Pharmacoeconomics Italian Research Articles
  Senior Editorial Advisor

Invited talks and conferences

• Developing economic evaluation methods: assessing the value of access to individual patient level data
  Erasmus University (The Netherlands)
  University of Amsterdam (The Netherlands)
  University of Maastricht (The Netherlands)
• NICE and the role of economic evaluation in the UK HTA process
  Catholic University of Chile (Chile), August 2010
• Methods to calculate medical costs in Europe: mission impossible?
  International Workshop "Combining Epidemiology and Economics for Measurement of Cancer Costs", Rome (Italy) September 2010
• Regression estimators for (health related) quality of life and QALYs ScHARR
  Health Economics and Decision Science, University of Sheffield
• Multilevel modelling in health economic evaluation: what it is and what it can do for you
  Academic Unit of Health Economics, University of Leeds
• Healthcare cost-effectiveness analysis: Why? Which? What? – A NICE example
  Food and Environmental Research Agency, York
• A bridge over the troubled water: integrating individual patient-level data analysis and comprehensive decision analytic cost-effectiveness modelling
  iBMG & iMTA, Erasmus University, Rotterdam, The Netherland
• Fragile - handle with care!   Issues in the long-term term extrapolation of individual patient level data for cost-effectiveness modelling
  MRC Clinical Trial Unit, London