Profile

Career

 

2007 -	Emeritus Professor	University of York
2005 - 2007	Professor	University of York
2001 - 2005	Reader	University of York
1997 - 2001	Senior lecturer	University of York
1971 - 1997	Lecturer	University of York
1969 - 1971	Postdoctoral Fellow	University of Bristol
1967 - 1969	Postdoctoral Fellow	University of California, Berkeley
1966	PhD Biophysical Chemistry	University of Birmingham
1963	BSc	University of Birmingham

Research

Overview

Research centres on the regulation of intestinal nutrient absorption. We have shown that the apical GLUT2 pathway of intestinal glucose absorption accounts for >75% of glucose absorbed during digestion. Under these conditions some 70% of calcium absorption occurs through the L-type channel Cav1.3. Our recent work focuses on the role of intestinal sweet and umami taste receptors in controlling nutrient absorption.

Discoveries

We discovered the major route calcium absorption across the small intestine during digestion. We provided the first functional demonstration of sweet taste receptors in the small intestine by showing that, together with calcium absorption, they control the major route of glucose absorption previously discovered by us.

Publications

Selected publications

Mace O J, Affleck JA, Patel N and Kellett GL (2007) Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2 Journal of Physiology 582.1: 379-352

Kellett GL, Brot-Laroche E, Mace OJ and Leturque A (2008) Sugar Absorption in the Intestine: The Role of GLUT2 Annual Reviews of Nutrition 21 28: 35-54

Mace OJ, Lister N, Morgan E, Shepherd E, Affleck J, Helliwell P, Bronk JR, Kellett GL, Meredith D, Boyd R, Pieri M, Bailey PD, Pettcrew R, Foley D (2009) An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine J Physiol. 587(1): 195-210